Tie-1 and Tie-2 tyrosine kinase receptors are expressed specifically on vascular endothelial
cells and on a certain subtype of macrophages implicated in angiogenesis, thus, they have …

Angiogenesis is involved in physiological and pathological processes in the body. Tumor
angiogenesis is a key factor associated with tumor growth, progression, and metastasis …

Malaria, a mosquito‐borne infectious disease caused by parasites of the genus Plasmodium
continues to be a major health problem worldwide. The unicellular Plasmodium‐parasites …

Angiopoietins (ANGPTs) are ligands of the endothelial cell receptor TIE2 and have crucial
roles in the tumour angiogenic switch. Increased expression of ANGPT2 relative to ANGPT1 …

Abstracts The Angiopoietin/Tie system acts as a vascular specific ligand/receptor system to
control endothelial cell survival and vascular maturation. The Angiopoietin family includes …

Angiopoietin-1 (Ang1) has powerful vascular protective effects: suppressing plasma
leakage, inhibiting vascular inflammation, and preventing endothelial death. Preclinical …

Angiopoietin 2 (Ang2) was originally shown to be a competitive antagonist for Ang1 of the
receptor tyrosine kinase Tie2 in endothelial cells (ECs). Since then, reports have conflicted …

Tumor angiogenesis is a key event that governs tumor progression and metastasis. It is
controlled by the complicated and coordinated actions of pro-angiogenic factors and their …

Simple Summary The dissemination of cancer cells from their original location to distant
organs where they grow, a process called metastasis, causes more than 90% of cancer …

The receptor tyrosine kinase Tie2, and its activating ligand Angiopoietin-1 (Ang1), are
required for vascular remodelling and vessel integrity, whereas Ang2 may counteract these …