Dendritic spines are small, thin, specialized protrusions from neuronal dendrites, primarily
localized in the excitatory synapses. Sophisticated imaging techniques revealed that …

Agomelatine is a selective agonist of melatonin receptor 1A/melatonin receptor 1B (MT 1/MT
2) and antagonist of 5-hydroxytryptamine 2C receptors. It is used clinically to treat major …

Agomelatine is an agonist of the melatonergic MT1/MT2 receptors and an antagonist of the
serotonergic 5-HT receptors. Its actions mimic melatonin in antioxidative and anti …

Previous data have shown that the rat model of melatonin deficit can cause a number of
neurobiological aberrations. The aim of the present study was to determine whether the …

Recent studies about the novel antidepressant agomelatine, which is a mixed MT 1 and MT
2 melatonin receptor agonist and 5HT 2C serotonin receptor antagonist possessing an …

In this study, we investigated the potential therapeutic effects of tofisopam, a 2, 3-
benzodiazepine derivative anxiolytic, on cognitive deficits in rats with scopolamine-induced …

Experimental findings suggest that the melatonin system has a beneficial role in models of
Alzheimer's disease (ADs). The aim of the present study was to explore whether the atypical …

Researches that are related to the central nervous system complications of diabetes have
indicated higher incidence of cognitive disorders in patients. Since the variety of nootropic …

Introduction Agomelatine is an atypical antidepressant drug enhancing norepinephrine and
dopamine liberation; nevertheless, additional mechanisms are considered for the drug's …

Aims This study was planned to examine the antinociceptive efficacy of agomelatine against
acute mechanical, thermal, and chemical nociceptive stimuli, as well as to determine the …