The mechanisms of sorafenib resistance in hepatocellular carcinoma: theoretical basis and therapeutic aspects

W Tang, Z Chen, W Zhang, Y Cheng, B Zhang… - Signal transduction and …, 2020 - nature.com
Sorafenib is a multikinase inhibitor capable of facilitating apoptosis, mitigating angiogenesis
and suppressing tumor cell proliferation. In late-stage hepatocellular carcinoma (HCC) …

Cancer nanotechnology: current status and perspectives

JA Kemp, YJ Kwon - Nano convergence, 2021 - Springer
Modern medicine has been waging a war on cancer for nearly a century with no tangible
end in sight. Cancer treatments have significantly progressed, but the need to increase …

Tumor innervation: peripheral nerves take control of the tumor microenvironment

SM Gysler, R Drapkin - The Journal of clinical investigation, 2021 - Am Soc Clin Investig
In recent decades, cancer research has expanded exponentially beyond the study of
abnormally dividing cells to include complex and extensive heterotypic interactions between …

Electrochemical nano biosensors for the detection of extracellular vesicles exosomes: From the benchtop to everywhere?

S Singh, A Numan, S Cinti - Biosensors and Bioelectronics, 2022 - Elsevier
Detection of extracellular vesicles (EVs) exosomes is a challenge to address the need for
better diagnostic tests and to create a point-of-care (POC) platform that can detect, monitor …

Exosomes: Isolation, characterization, and biomedical applications

GN Alzhrani, ST Alanazi, SY Alsharif… - Cell Biology …, 2021 - Wiley Online Library
Exosomes are nano‐sized bioactive vesicles of 30–150 nm in diameter. They are secreted
by exocytosis of nearly all type of cells in to the extracellular fluid. Thereby, they can be …

Dissecting the theranostic potential of exosomes in autoimmune disorders

VP Jayaseelan, P Arumugam - Cellular & molecular immunology, 2019 - nature.com
The biology of exosomes is a fascinating field of science that has attracted much attention
from clinical researchers due to the plethora of associated applications. These biological …

Point-of-care cancer diagnostic devices: From academic research to clinical translation

L Syedmoradi, ML Norton, K Omidfar - Talanta, 2021 - Elsevier
Early and timely diagnosis of cancer plays a decisive role in appropriate treatment and
improves clinical outcomes, improving public health. Significant advances in biosensor …

Recent advances in microfluidic approaches for the isolation and detection of exosomes

K Kumar, E Kim, M Alhammadi, U Reddicherla… - TrAC Trends in …, 2023 - Elsevier
Exosomes are nano-sized extracellular vesicles secreted by most types of cells which
facilitate intercellular communication by delivering molecular cargoes (eg, nucleic acids and …

Translating extracellular vesicle packaging into therapeutic applications

DC Ozkocak, TK Phan, IKH Poon - Frontiers in immunology, 2022 - frontiersin.org
Extracellular vesicles (EVs) are membrane-bound particles released by cells in various
(patho) physiological conditions. EVs can transfer effector molecules and elicit potent …

Aptamer-based biosensing detection for exosomes: from selection to aptasensors

L Zheng, G Yang, I Muhammad, F Qu - TrAC Trends in Analytical Chemistry, 2024 - Elsevier
Exosomes reflect their source cells' phenotypic state, making them key biomarkers for
tumors, cardiovascular diseases, neurodegenerative diseases, and immune responses …