There is a lack of appropriate melanoma models that can be used to evaluate the efficacy of
novel therapeutic modalities. Here, we discuss the current state of the art of melanoma …

Ultraviolet (UV) light is absorbed by nucleic acids, proteins or other endogenous
chromophores, such as porphyrins, flavins and melanin, triggering biological processes in …

Although immunotherapy has revolutionized cancer treatment, only a subset of patients
demonstrate durable clinical benefit. Definitive predictive biomarkers and targets to …

Mucosal melanoma is a rare and poorly characterized subtype of human melanoma. Here
we perform a cross-species analysis by sequencing tumor-germline pairs from 46 primary …

The melanoma genome is dominated by ultraviolet radiation (UVR)-induced mutations.
Their relevance in disease progression is unknown. Here we classify melanomas by …

Melanoma is recognized as the most dangerous type of skin cancer, with high mortality and
resistance to currently used treatments. To overcome the limitations of the available …

Melanoma is one of the most lethal types of skin cancer, with a poor prognosis once the
disease enters metastasis. The efficacy of currently available treatment schemes for …

Ultraviolet (UV) irradiation is a serious problem for skin health thus the interest in the
research to develop sunscreen agent has been increasing. Chalcone is a promising …

Parkinson's disease (PD) is a neurodegenerative disorder associated with the death of
dopaminergic neurons within the substantia nigra of the brain. Melanoma is a cancer of …

Although antioxidants promote melanoma metastasis, the role of reactive oxygen species
(ROS) in other stages of melanoma progression is controversial. Moreover, genes regulating …