In recent years, accumulating evidence has elucidated the role of lysosomes in dynamically
regulating cellular and organismal homeostasis. Lysosomal changes and dysfunction have …

Senescence is a cellular program that prevents the replication of old, damaged, or
cancerous cells. Senescent cells become growth arrested and undergo changes in their …

Lysosomes are the main organelles in macrophages for killing invading bacteria. However,
the precise mechanism underlying lysosomal biogenesis upon bacterial infection remains …

Lysosomes play important roles in cellular degradation to maintain cell homeostasis. In
order to understand whether and how lysosomes alter with age and contribute to lifespan …

Extracellular acidification occurs in inflamed tissue and the tumor microenvironment;
however, a systematic study on how pH sensing contributes to tissue homeostasis is lacking …

Parkinson's disease (PD) is a neurodegenerative, progressive disease without a cure. To
prevent PD onset or at least limit neurodegeneration, a better understanding of the …

Cells can rapidly adjust their proteomes in dynamic environments by regulating mRNA
translation. There is mounting evidence that dysregulation of mRNA translation supports the …

Neuroinflammation has been recognized as a component of Alzheimer's Disease (AD)
pathology since the original descriptions by Alois Alzheimer and a role for infections in AD …

Phagocytosis is a dynamic process that requires an intricate interplay between phagocytic
receptors, membrane lipids, and numerous signalling proteins and their effectors, to …

Senescence is a cellular state which involves cell cycle arrest and a proinflammatory
phenotype, and it has traditionally been associated with cellular and organismal aging …