Mesenchymal stem cells (MSCs) have been widely studied as a versatile cell source for
tissue regeneration and remodeling due to their potent bioactivity, which includes …

Bone-related maladies are a major health burden on modern society. Loss of skeletal
integrity and regeneration capacity through aging, obesity, and disease follows from a …

Loss of skeletal integrity during ageing and disease is associated with an imbalance in the
opposing actions of osteoblasts and osteoclasts. Here we show that intrinsic ageing of …

Restoring joint homeostasis is crucial for relieving osteoarthritis (OA). Current strategies are
limited to unilateral efforts in joint lubrication, inhibition of inflammation, free radicals …

Growth plate cartilage has limited self-repair ability, leading to poor bone bridge formation
post-injury and ultimately limb growth defects in children. The current corrective surgeries …

Specialized connective tissues, including bone and adipose tissues, control various
physiological activities, including mineral and energy homeostasis. However, the identity of …

Growth hormone (GH) and its mediator, the insulin-like growth factor-1 (IGF-1) regulate
somatic growth, metabolism and many aspects of aging. As such, actions of GH/IGF have …

The mechanisms underlying bone development, repair and regeneration are reliant on the
interplay and communication between osteoclasts and other surrounding cells. Osteoclasts …

The bone marrow contains various populations of skeletal stem cells (SSCs) in the stromal
compartment, which are important regulators of bone formation. It is well-described that …

The ontogeny and fate of stem cells have been extensively investigated by lineage-tracing
approaches. At distinct anatomical sites, bone tissue harbors multiple types of skeletal stem …