Obesity is a complex, chronic disease and global public health challenge. Characterized by
excessive fat accumulation in the body, obesity sharply increases the risk of several …

The formation of adipocytes during embryogenesis has been largely understudied.
However, preadipocytes appear to originate from multipotent mesenchymal stromal/stem …

Adipocytes arising from mesenchymal stem cells (MSCs) requires MSC adipocyte
commitment and differentiation of preadipocytes to mature adipocytes. Several signaling …

Red blood cells mature within the erythroblastic island (EI) niche that consists of specialized
macrophages surrounded by differentiating erythroblasts. Here we establish an in vitro …

Adipose tissues are essential for actively regulating systemic energy balance, glucose
homeostasis, immune responses, reproduction, and longevity. Adipocytes maintain dynamic …

Signaling networks guide stem cells during their lineage specification and terminal
differentiation. Primary cilium, an antenna-like protrusion, directly or indirectly plays a …

Objective Dysfunctional, unhealthy expansion of white adipose tissue due to excess dietary
intake is a process at the root of obesity and Type 2 Diabetes development. The objective of …

SerpinB2 (plasminogen activator inhibitor type 2) has been called the “undecided serpin”
with no clear consensus on its physiological role, although it is well described as an inhibitor …

The mesenchymal stem cells have multidirectional differentiation potential and can
differentiate into adipocytes, osteoblasts, cartilage tissue, muscle cells and so on. The …

Targeting regulatory signaling pathways that control human bone marrow stromal (skeletal
or mesenchymal) stem cell (hBMSC) differentiation and lineage fate determination is gaining …