Highlights•Drug repurposing may be a novel approach towards developing adjunct therapy
for stroke.•Drug repurposing avoids time and expenses associated with new drug-discovery …

Abstract F 1 FO ATP synthase is responsible for the production of> 95% of all ATP synthesis
within the cell. Dysregulation of its expression, activity or localization is linked to various …

Loss of the gene (Fmr1) encoding Fragile X mental retardation protein (FMRP) causes
increased mRNA translation and aberrant synaptic development. We find neurons of the …

Aims: Neuroinflammation and oxidative stress are deemed the prime causes of brain injury
after cerebral ischemia/reperfusion (I/R). Since the silent mating-type information regulation …

Deciphering the factors causing damage to white matter fiber bundles and exploring new
strategies to alleviate white matter injury (WMI) is a promising treatment to improve …

Current drug development strategies devote extensive effort to identifying the molecular
mechanism of action of new drug candidates. Often, if more than one unrelated enzyme or …

Mitochondria are double-membrane organelles that provide the majority of a cell's energy.
Furthermore, mitochondria are involved in various cellular biological activities, including …

Selective targeting of sodium channel subtypes Nav1. 7, Nav1. 8, and Nav1. 9, preferentially
expressed by peripheral nociceptors, represents a unique opportunity to develop analgesics …

Traumatic brain injury (TBI) represents one of the major public health concerns worldwide
due to the increase in TBI incidence as a result of injuries from daily life accidents such as …

Natural products (NPs) and their structural analogs represent a major source of novel drug
development for disease prevention and treatment. The development of new drugs from NPs …