Agmatine is an endogenous neuromodulator that, based on animal studies, has the
potential for new drug development. As an endogenous aminoguanidine compound (1 …

Agmatine, the decarboxylation product of arginine, was largely neglected as an important
player in mammalian metabolism until the mid-1990s, when it was re-discovered as an …

Agmatine is a polyamine that is produced via decarboxylation of l-arginine by the enzyme
arginine decarboxylase. It binds to various receptors and has been accepted as a novel …

Targeting analgesic drugs for spinal delivery reflects the fact that while the conscious
experience of pain is mediated supraspinally, input initiated by high intensity stimuli, tissue …

Background and purpose: Post‐synaptic density protein 95 (PSD95) contains three
PSD95/Dosophilia disc large/ZO‐1 homology domains and links neuronal nitric oxide …

Recent findings demonstrated the dysregulation of imidazoline receptor binding sites in
major depression and their normalization by chronic treatment with antidepressants …

Present study investigated the role of agmatine in ethanol-induced anxiolysis and
withdrawal anxiety using elevated plus maze (EPM) test in rats. The anxiolytic-like effect of …

J. Neurochem.(2011) 116, 67–75. Abstract Agmatine, an endogenous arginine metabolite,
has been proposed as a novel neuromodulator that plays protective roles in the CNS in …

Pain remains a major clinical challenge because there are no effective analgesics for some
pain conditions and the mainstay analgesics for severe pain, opioids, have serious …

Putrescine, a polyamine present at high concentrations in the mammalian brain, was
suggested to play a role in the modulation of depression. Thus, this study investigated the …