Reactive oxygen species (ROS) are a group of short-lived, highly reactive, oxygen-
containing molecules that can induce DNA damage and affect the DNA damage response …

In the course of examining the effect of electric fields on the growth of Escherichia coli cells,
a biological activity of platinum compounds was uncovered that led to the development of …

Thirty years after the onset of the first clinical studies with cisplatin, the development of
antineoplastic platinum drugs continues to be a productive field of research. This article …

Iron metabolism and tumor biology are intimately linked. Iron facilitates the production of
oxygen radicals, which may either result in iron-induced cell death, ferroptosis, or contribute …

While chemotherapeutic agents have yielded relative success in the treatment of cancer,
patients are often plagued with unwanted and even debilitating side-effects from the …

How mitochondria process DNA damage and whether a change in the steady-state level of
mitochondrial DNA damage (mtDNA) contributes to mitochondrial dysfunction are questions …

A number of studies have demonstrated the presence of mitochondrial DNA (mtDNA)
mutations in cancer cells. In this article, we review mitochondrial genomic aberrations …

Alterations in mitochondrial structure and functions have long been observed in cancer cells.
Targeting mitochondria as a cancer therapeutic strategy has gained momentum in the recent …

The development of multifunctional agents that could be used for simultaneous tumor
targeting, imaging and treatment is a major goal in cancer research and is expected to …

The cellular distribution and processing pathways of two platinum compounds, modeling the
antitumor drug cisplatin (cDDP) in human osteosarcoma (U2-OS) cells is reported. A [Pt (en) …