Metabolomics and malaria biology

V Lakshmanan, KY Rhee, JP Daily - Molecular and biochemical …, 2011 - Elsevier
Metabolomics has ushered in a novel and multi-disciplinary realm in biological research. It
has provided researchers with a platform to combine powerful biochemical, statistical …

Plasmodium immunomics

DL Doolan - International journal for parasitology, 2011 - Elsevier
The Plasmodium parasite, the causative agent of malaria, is an excellent model for
immunomic-based approaches to vaccine development. The Plasmodium parasite has a …

New antigens for a multicomponent blood-stage malaria vaccine

FH Osier, MJ Mackinnon, C Crosnier, G Fegan… - Science translational …, 2014 - science.org
An effective blood-stage vaccine against Plasmodium falciparum remains a research
priority, but the number of antigens that have been translated into multicomponent vaccines …

[HTML][HTML] A full-length recombinant Plasmodium falciparum PfRH5 protein induces inhibitory antibodies that are effective across common PfRH5 genetic variants

LY Bustamante, SJ Bartholdson, C Crosnier… - Vaccine, 2013 - Elsevier
The lack of an effective licensed vaccine remains one of the most significant gaps in the
portfolio of tools being developed to eliminate Plasmodium falciparum malaria. Vaccines …

A library of functional recombinant cell-surface and secreted P. falciparum merozoite proteins

C Crosnier, M Wanaguru, B McDade, FH Osier… - Molecular & Cellular …, 2013 - ASBMB
Malaria, an infectious disease caused by parasites of the Plasmodium genus, is one of the
world's major public health concerns causing up to a million deaths annually, mostly …

RH5–Basigin interaction plays a major role in the host tropism of Plasmodium falciparum

M Wanaguru, W Liu, BH Hahn… - Proceedings of the …, 2013 - National Acad Sciences
Plasmodium falciparum, the cause of almost all human malaria mortality, is a member of the
Laverania subgenus which infects African great apes. Interestingly, Laverania parasites …

Plasmodium Kinases As Targets For New-Generation Antimalarials

IS Lucet, A Tobin, D Drewry, AF Wilks… - Future medicinal …, 2012 - Taylor & Francis
There is an urgent need for the development of new antimalarial drugs with novel modes of
actions. The malarial parasite, Plasmodium falciparum, has a relatively small kinome of< …

Histidine affinity tags affect MSP142 structural stability and immunodominance in mice

F Khan, PM Legler, RM Mease, EH Duncan… - Biotechnology …, 2012 - Wiley Online Library
Inclusion of affinity tags has greatly facilitated process development for protein antigens,
primarily for their recovery from complex mixtures. Although generally viewed as supportive …

Vaccine candidate discovery for the next generation of malaria vaccines

J Tuju, G Kamuyu, LM Murungi, FHA Osier - Immunology, 2017 - Wiley Online Library
Although epidemiological observations, IgG passive transfer studies and experimental
infections in humans all support the feasibility of developing highly effective malaria …

Preliminary characterization of Plasmodium vivax sporozoite antigens as pre-erythrocytic vaccine candidates

J Nicholas, SL De, P Thawornpan… - PLoS Neglected …, 2023 - journals.plos.org
Plasmodium vivax pre-erythrocytic (PE) vaccine research has lagged far behind efforts to
develop Plasmodium falciparum vaccines. There is a critical gap in our knowledge of PE …