Errors occurring during DNA replication can result in inaccurate replication, incomplete
replication, or re-replication, resulting in genome instability that can lead to diseases such as …

The assembly of a functional kinetochore on centromeric chromatin is necessary to connect
chromosomes to the mitotic spindle, ensuring accurate chromosome segregation. This …

Kinetochores are multiprotein assemblies directing mitotic spindle attachment and
chromosome segregation. In apicomplexan parasites, most known kinetochore components …

Metamonads are a diverse group of heterotrophic microbial eukaryotes adapted to living in
hypoxic environments. All metamonads but one harbour metabolically altered …

Kinetochores are the macromolecular protein complexes that govern chromosome
movement by binding spindle microtubules during mitosis and meiosis. Centromeres are the …

Background Intracellular symbionts often undergo genome reduction, losing both coding
and non-coding DNA in a process that ultimately produces small, gene-dense genomes with …

The notion that mitochondria cannot be lost was shattered with the report of an oxymonad
Monocercomonoides exilis, the first eukaryote arguably without any mitochondrion. Yet …

Inteins are self-splicing protein elements found in viruses and all three domains of life. How
the DNA encoding these selfish elements spreads within and between genomes is poorly …

Symbiotic relationships between eukaryotes and prokaryotes played pivotal roles in the
evolution of life and drove the emergence of specialized symbiotic structures in animals …

Eukaryotic DNA replication initiates from multiple genomic loci known as origins. At budding
yeast origins like ARS1, a double hexamer (DH) of the MCM replicative helicase is …