Cellular senescence, classically defined as stable cell cycle arrest, is implicated in biological
processes such as embryogenesis, wound healing and ageing. Senescent cells have a …

Cardiac ageing manifests as a decline in function leading to heart failure. At the cellular
level, ageing entails decreased replicative capacity and dysregulation of cellular processes …

Proviral integration site for Moloney murine leukemia virus-1 (Pim-1) is a serine/threonine
kinase that regulates multiple cellular functions such as cell cycle, cell survival, drug …

Background PIM kinases are well-studied drug targets for cancer, belonging to
Serine/Threonine kinases family. They are the downstream target of various signaling …

Background: Pim1 kinase plays an important role in cell division, survival, and commitment
of precursor cells towards a myocardial lineage, and overexpression of Pim1 in ckit+ cardiac …

Cardiac Progenitor Cells (CPCs) show great potential as a cell resource for restoring cardiac
function in patients affected by heart disease or heart failure. CPCs are proliferative and …

The immune response to a chronic viral infection is uniquely tailored to balance viral control
and immunopathology. The role of myeloid cells in shaping the response to chronic viral …

Abstract The Proviral Integration of Molony murine leukemia virus (PIM)-1 protein contributes
to the solid cancers and hematologic malignancies, cell growth, proliferation, differentiation …

Key points While autologous stem cell‐based therapies are currently being tested on elderly
patients, there are limited data on the function of aged stem cells and in particular c‐kit+ …

Enhancing cardiomyocyte survival is crucial to blunt deterioration of myocardial structure
and function following pathological damage. PIM1 (Proviral Insertion site in Murine leukemia …