Raman spectroscopy, as a label-free optical technology, has widely applied in tumor
diagnosis. Relying on the different Raman technologies, conventional diagnostic methods …

Glioblastoma (GBM) is a highly aggressive disease and is associated with poor prognosis
despite treatment advances in recent years. Surgical resection of tumor remains the main …

Stereotactic brain biopsy is one of the most frequently performed brain surgeries. This
review aimed to expose the latest cutting-edge and updated technologies and innovations …

Intraoperative histopathological examinations are routinely performed to provide
neurosurgeons with information about the entity of tumor tissue. Here, we quantified the …

Objectives To investigate whether in patients undergoing surgery for oral squamous cell
carcinoma, stimulated Raman histology (SRH), in comparison with H&E-stained frozen …

Introduction The intrinsic autofluorescence of biological tissues interferes with the detection
of fluorophores administered for fluorescence guidance, an emerging auxiliary technique in …

Stimulated Raman histology (SRH) is an ex vivo optical imaging method that enables
microscopic examination of fresh tissue intraoperatively. The conventional intraoperative …

Background The study of the distinct structure and function of the human central nervous
system, both in healthy and diseased states, is becoming increasingly significant in the field …

Single-cell RNA-sequencing (scRNA-seq) is becoming a ubiquitous method in profiling the
cellular transcriptomes of both malignant and non-malignant cells from the human brain …

Frozen section biopsy, introduced in the early 1900s, still remains the gold standard
methodology for rapid histologic evaluations. Although a valuable tool, it is labor-, time-, and …