Current treatment guidelines refer to small cell lung cancer (SCLC), one of the deadliest
human malignancies, as a homogeneous disease. Accordingly, SCLC therapy comprises …

Tuft cells are a rare chemosensory lineage that coordinates immune and neural responses
to foreign pathogens in mucosal tissues. Recent studies have also revealed tuft-cell-like …

Tuft cells are a rare and morphologically distinct chemosensory cell type found throughout
many organs, including the gastrointestinal tract. These cells were identified by their unique …

Tuft cells in mucosal tissues are key regulators of type 2 immunity. Here, we examined the
impact of the microbiota on tuft cell biology in the intestine. Succinate induction of tuft cells …

It is very urgent to construct an efficient neuron-specific enolase (NSE) immunosensor for the
early diagnosis of small cell lung cancer (SCLC). Here, a sensitive NSE immunosandwich …

We report an approach for cancer phenotyping based on targeted sequencing of cell-free
DNA (cfDNA) for small cell lung cancer (SCLC). In SCLC, differential activation of …

Dear Editor, An ideal cancer therapy drug should kill cancer cells while displaying limited
toxicities toward normal cells 1. Therefore, genes essential in cancer but not normal cells are …

Significant advancements have been achieved in the area of molecular targeted therapy for
lung adenocarcinoma (LUAD). However, the complex molecular patterns and high …

During recent years chemosensory cells in extraoral tissues have been established as
mediators for the detection and regulation of innate immune processes in response to …

Chemosensory epithelial tuft cells contribute to innate immunity at barrier surfaces, but their
differentiation from epithelial progenitors is not well understood. Here, we exploited …