Dynamic DNA devices and assemblies formed by shape-complementary, non–base pairing 3D components
We demonstrate that discrete three-dimensional (3D) DNA components can specifically self-
assemble in solution on the basis of shape-complementarity and without base pairing. Using …
assemble in solution on the basis of shape-complementarity and without base pairing. Using …
Bacterial ribonucleases and their roles in RNA metabolism
DH Bechhofer, MP Deutscher - Critical reviews in biochemistry and …, 2019 - Taylor & Francis
Ribonucleases (RNases) are mediators in most reactions of RNA metabolism. In recent
years, there has been a surge of new information about RNases and the roles they play in …
years, there has been a surge of new information about RNases and the roles they play in …
Protein embeddings and deep learning predict binding residues for various ligand classes
One important aspect of protein function is the binding of proteins to ligands, including small
molecules, metal ions, and macromolecules such as DNA or RNA. Despite decades of …
molecules, metal ions, and macromolecules such as DNA or RNA. Despite decades of …
Structural basis of RNA processing by human mitochondrial RNase P
Human mitochondrial transcripts contain messenger and ribosomal RNAs flanked by
transfer RNAs (tRNAs), which are excised by mitochondrial RNase (mtRNase) P and Z to …
transfer RNAs (tRNAs), which are excised by mitochondrial RNase (mtRNase) P and Z to …
The molecular interactions that stabilize RNA tertiary structure: RNA motifs, patterns, and networks
SE Butcher, AM Pyle - Accounts of chemical research, 2011 - ACS Publications
RNA molecules adopt specific three-dimensional structures critical to their function. Many
essential metabolic processes, including protein synthesis and RNA splicing, are carried out …
essential metabolic processes, including protein synthesis and RNA splicing, are carried out …
3D RNA and functional interactions from evolutionary couplings
Non-coding RNAs are ubiquitous, but the discovery of new RNA gene sequences far
outpaces the research on the structure and functional interactions of these RNA gene …
outpaces the research on the structure and functional interactions of these RNA gene …
Structural basis of MALAT1 RNA maturation and mascRNA biogenesis
The metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) long noncoding
RNA (lncRNA) has key roles in regulating transcription, splicing, tumorigenesis, etc. Its …
RNA (lncRNA) has key roles in regulating transcription, splicing, tumorigenesis, etc. Its …
How does RNA fold dynamically?
Recent advances in interrogating RNA folding dynamics have shown the classical model of
RNA folding to be incomplete. Here, we pose three prominent questions for the field that are …
RNA folding to be incomplete. Here, we pose three prominent questions for the field that are …
Nucleic acid catalysis: metals, nucleobases, and other cofactors
WL Ward, K Plakos, VJ DeRose - Chemical reviews, 2014 - ACS Publications
The discovery of RNA-catalyzed phosphodiester bond cleavage by Cech and Altman in
1982− 1983 shattered the paradigm of protein-dependent biological catalysis and opened …
1982− 1983 shattered the paradigm of protein-dependent biological catalysis and opened …
Structure of the OMEGA nickase IsrB in complex with ωRNA and target DNA
RNA-guided systems, such as CRISPR–Cas, combine programmable substrate recognition
with enzymatic function, a combination that has been used advantageously to develop …
with enzymatic function, a combination that has been used advantageously to develop …