Cystic kidneys are common causes of end-stage renal disease, both in children and in
adults. Autosomal dominant polycystic kidney disease (ADPKD) and autosomal recessive …

The lymphatic system (LS) is composed of lymphoid organs and a network of vessels that
transport interstitial fluid, antigens, lipids, cholesterol, immune cells, and other materials in …

The kidney is permeated by a highly complex vascular system with glomerular and
peritubular capillary networks that are essential for maintaining the normal functions of …

Lymphatic vessels drain excess tissue fluids to maintain the interstitial environment.
Lymphatic capillaries develop during the progression of tissue fibrosis in various clinical and …

The mammalian vascular system consists of two networks: the blood vascular system and
the lymphatic vascular system. Throughout the body, the lymphatic system contributes to …

Polycystic kidney disease (PKD) is a multiorgan disorder resulting in fluid-filled cyst
formation in the kidneys and other systems. The replacement of kidney parenchyma with an …

Background Autosomal dominant polycystic kidney disease (ADPKD) is a genetic ciliopathy
disease characterized by progressive formation and enlargement of cysts in multiple organs …

Renal fibrosis is the final common pathway of chronic kidney diseases. Lymphatic vessel
(LV) proliferation is found in human renal diseases and other fibrotic diseases, suggesting …

Elevated levels of vascular endothelial growth factor (VEGF) A are thought to cause
glomerular endothelial cell (GEnC) dysfunction and albuminuria in diabetic nephropathy …

Heterogeneity of lymphatic vessels during embryogenesis is critical for organ-specific
lymphatic function. Little is known about lymphatics in the developing kidney, despite their …