[HTML][HTML] Spasmolytic and Uroprotective Effects of Apigenin by Downregulation of TGF-β and iNOS Pathways and Upregulation of Antioxidant Mechanisms: In Vitro and …

I Anjum, A Mobashar, S Jahan, S Najm, HA Nafidi… - Pharmaceuticals, 2023 - mdpi.com
Apigenin is a phytochemical obtained from Chamomilla recutita. Its role in interstitial cystitis
is not yet known. The present study is aimed at understanding the uroprotective and …

[HTML][HTML] Caftaric Acid Ameliorates Oxidative Stress, Inflammation, and Bladder Overactivity in Rats Having Interstitial Cystitis: An In Silico Study

I Anjum, S Najm, K Barkat, HA Nafidi, YAB Jardan… - ACS …, 2023 - ncbi.nlm.nih.gov
Interstitial cystitis (IC) is the principal unwanted effect associated with the use of
cyclophosphamide (CYP). It results in increased oxidative stress, overexpression of …

Caftaric Acid Ameliorates Oxidative Stress, Inflammation, and Bladder Overactivity in Rats Having Interstitial Cystitis: An In Silico Study

Saima, I Anjum, S Najm, K Barkat, HA Nafidi… - ACS …, 2023 - ACS Publications
Interstitial cystitis (IC) is the principal unwanted effect associated with the use of
cyclophosphamide (CYP). It results in increased oxidative stress, overexpression of …

Epileptic Targets and Drugs: A Mini-Review

TCML Rodrigues, JP de Moura… - Current Drug …, 2023 - ingentaconnect.com
Background: Epilepsy is a neurological disease affected by an imbalance of inhibitory and
excitatory signaling in the brain. Introduction: In this disease, the targets are active in …

The anti-cancer potential of 2, 4, 6 tris-methyphenylamino1, 3, 5-triazine compound against mammary glands cancer: Via down-regulating the hormonal, inflammatory …

Y Mehmood, F Anwar, U Saleem, S Hira, B Ahmad… - Life Sciences, 2021 - Elsevier
Aim of the study Breast cancer is caused by abnormal growth of the cells and progressed
due to the over-expression of estrogen (ER) and progesterone (PR). The current study was …

Uroprotective Potential of Campesterol in Cyclophosphamide Induced Interstitial Cystitis; Molecular Docking Studies

J Javed, I Anjum, S Najm, N Ali… - Chemistry & …, 2023 - Wiley Online Library
Cyclophosphamide (CYP) is commonly used to treat cancer of the ovaries, breast, lymph,
and blood system and produces interstitial cystitis (IC) via its urotoxic metabolite: ie, acrolein …

Metal complexes of pregabalin: Design, synthesis, characterization and biological evaluation

A Asbat, S Najm, MM Khan, J Iqbal, MA Syed… - Journal of Molecular …, 2021 - Elsevier
In the current study, a series of Schiff base derivatives of pregabalin are complexed with zinc
and copper, and characterized by spectroscopic techniques and biological assays. Docking …

The Structure-Activity Relatıonships of Familiar Antiepileptic Drugs and Na+ Channels

EN Cakmak, M Gür, B Kıran - Hittite Journal of Science and …, 2022 - dergipark.org.tr
The aim of this study is to examine the effects of drug active compounds, which are widely
used in the treatment of epilepsy, on voltage-gated Na+ channels are important channels …