Acute pain signaling has a key protective role and is highly evolutionarily conserved.
Chronic pain, however, is maladaptive, occurring as a consequence of injury and disease …

Pre-diabetes and diabetes are a global epidemic, and the associated neuropathic
complications create a substantial burden on both the afflicted patients and society as a …

Injury to or disease of the nervous system can invoke chronic and sometimes intractable
neuropathic pain. Many parallel, interdependent, and time-dependent processes, including …

Neuropathic pain arises as a consequence of a lesion or disease affecting the
somatosensory system. It is generally chronic and challenging to treat. The recommended …

The global epidemic of prediabetes and diabetes has led to a corresponding epidemic of
complications of these disorders. The most prevalent complication is neuropathy, of which …

Despite the importance of pain as a warning physiological system, chronic neuropathic pain
is frequently caused by damage in the nervous system, followed by persistence over a long …

Moderate-to-severe pain is a common problem experienced by patients with cancer.
Although analgesic drugs are effective, adverse side effects are common and some …

The mechanisms by which noxious stimuli produce the sensation of pain in animals are
complex. Noxious stimuli are transduced at the periphery and transmitted to the CNS, where …

Neuropathic pain arises from injury to the nervous system. Conditions associated with
neuropathic pain are diverse, and lesions and/or pathological changes in the central …

Tissue or nerve injury induces widespread plastic changes from the periphery and spinal
cord up to the cortex, resulting in chronic pain. Although many clinicians and researchers …