The interplay among oxidative stress, brain insulin resistance and AMPK dysfunction contribute to neurodegeneration in type 2 diabetes and Alzheimer disease

E Barone, F Di Domenico, M Perluigi… - Free Radical Biology and …, 2021 - Elsevier
Alzheimer's disease (AD) is the most common form of dementia in the elderly followed by
vascular dementia. In addition to clinically diagnosed dementia, cognitive dysfunction has …

The value of neuroimaging in dementia diagnosis

CA Raji, TLS Benzinger - CONTINUUM: Lifelong Learning in …, 2022 - journals.lww.com
The Value of Neuroimaging in Dementia Diagnosis : CONTINUUM: Lifelong Learning in
Neurology Account Register Activate Subscription Help Subscribe American Academy of …

Obesity-induced neuroinflammation and cognitive impairment in young adult versus middle-aged mice

RE Henn, SE Elzinga, E Glass, R Parent, K Guo… - Immunity & …, 2022 - Springer
Background Obesity rates are increasing worldwide. Obesity leads to many complications,
including predisposing individuals to the development of cognitive impairment as they age …

Diabetes and dementia: Clinical perspective, innovation, knowledge gaps

MG Savelieff, KS Chen, SE Elzinga… - Journal of Diabetes and its …, 2022 - Elsevier
The world faces a pandemic-level prevalence of type 2 diabetes. In parallel with this
massive burden of metabolic disease is the growing prevalence of dementia as the …

Cognitive dysfunction in diabetes: abnormal glucose metabolic regulation in the brain

S Zhang, Y Zhang, Z Wen, YN Yang, T Bu… - Frontiers in …, 2023 - frontiersin.org
Cognitive dysfunction is increasingly recognized as a complication and comorbidity of
diabetes, supported by evidence of abnormal brain structure and function. Although few …

The cognitive improvement and alleviation of brain hypermetabolism caused by FFAR3 ablation in Tg2576 mice is persistent under diet-induced obesity

M Solas, M Zamarbide, CG Ardanaz… - International Journal of …, 2022 - mdpi.com
Obesity and aging are becoming increasingly prevalent across the globe. It has been
established that aging is the major risk factor for Alzheimer's disease (AD), and it is …

Astrocytes at the intersection of ageing, obesity, and neurodegeneration

W Firth, KR Pye, PG Weightman Potter - Clinical Science, 2024 - portlandpress.com
Once considered passive cells of the central nervous system (CNS), glia are now known to
actively maintain the CNS parenchyma; in recent years, the evidence for glial functions in …

Imaging Correlates between Headache and Breast Cancer: An [18F]FDG PET Study

L Antunovic, A Artesani, A Viganò, A Chiti, A Santoro… - Cancers, 2023 - mdpi.com
Simple Summary [18F] Fluorodeoxyglucose ([18F] FDG) positron emission tomography
(PET) provides information about metabolic patterns of different diseases and conditions …

Glyoxalase 1 overexpression improves neurovascular coupling and limits development of mild cognitive impairment in a mouse model of type 1 diabetes

E Berends, MG Pencheva… - The Journal of …, 2024 - Wiley Online Library
Diabetes is associated with cognitive impairment, but the underlying mechanism remains
unclear. Methylglyoxal (MGO), a precursor to advanced glycation endproducts (AGEs), is …

Long-term outcomes in antibody-negative autoimmune encephalitis: a retrospective study

G Mangioris, E Orozco, D Dubey, EP Flanagan… - Journal of …, 2024 - Springer
Background and objective Despite constituting one-third of suspected autoimmune
encephalitis (AE) patients, antibody-negative cases without typical AE features are …