Type 2 diabetes is characterized by a two-to fourfold increased risk of cardiovascular
disease. This is generally attributed to the adverse effects of hyperglycemia and oxidative …

Diabetes mellitus is associated with an increased risk of cardiovascular disease, even in the
presence of intensive glycemic control. Substantial clinical and experimental evidence …

In the recent decades, oxidative stress has become focus of interest in most biomedical
disciplines and many types of clinical research. Increasing evidence from research on …

Background The vascular endothelium represents a fundamental mechanical and biological
barrier for the maintenance of vascular homeostasis along the entire vascular tree. Changes …

Cardiovascular disease (CVD) accounts for the largest number of deaths worldwide,
necessitating the development of novel treatments and prevention strategies. Given the …

Impaired cardiac microvascular function contributes to cardiovascular complications in
diabetes. Glucagon-like peptide-1 (GLP-1) exhibits potential cardioprotective properties in …

Erectile dysfunction (ED) is a common complication of diabetes, affecting up to 75% of all
diabetic men. Although the aetiology of diabetic ED is multifactorial, endothelial dysfunction …

OBJECTIVE Reduction of bone marrow–derived circulating progenitor cells has been
proposed as a novel mechanism of cardiovascular disease in type 2 diabetes. The present …

Humans are not programmed to be inactive. The combination of both accelerated sedentary
lifestyle and constant food availability disturbs ancient metabolic processes leading to …

O-GlcNAc glycosylation (O-GlcNAcylation) corresponds to the addition of N-
acetylglucosamine on serine and threonine residues of cytosolic and nuclear proteins. O …