The observation that phenotypic variability is ubiquitous in isogenic populations has led to a
multitude of experimental and theoretical studies seeking to probe the causes and …

Cell growth and gene expression, two essential elements of all living systems, have long
been the focus of biophysical interrogation. Advances in experimental single-cell methods …

Over the course of multiple divisions, cells accumulate diverse nongenetic, somatic damage
including misfolded and aggregated proteins and cell wall defects. If the rate of damage …

Asymmetric damage segregation (ADS) is ubiquitous among unicellular organisms: After a
mother cell divides, its two daughter cells receive sometimes slightly, sometimes strongly …

By diversifying, cells in a clonal population can together overcome the limits of individuals.
Diversity in single-cell growth rates allows the population to survive environmental stresses …

Over the course of multiple divisions, cells accumulate diverse non-genetic, somatic damage
including misfolded and aggregated proteins and cell wall defects. If the rate of damage …

In my PhD thesis, I use simplified mathematical models to study emergent phenomena of
various biological systems. In Chapter 1, I give an overview of how the tools from theoretical …