Despite the success of antiretroviral therapy (ART) for people living with HIV, lifelong
treatment is required and there is no cure. HIV can integrate in the host genome and persist …

The nuclear pore complex (NPC) serves as the sole bidirectional gateway of
macromolecules in and out of the nucleus. Owing to its size and complexity (∼ 1,000 protein …

Summary Human immunodeficiency virus (HIV-1) remains a major health threat. Viral capsid
uncoating and nuclear import of the viral genome are critical for productive infection. The …

Epidemiological data from the Center of Disease Control (CDC) and the World Health
Organization (WHO) statistics in 2017 show that 10.0 million people around the world …

HIV-1 capsid core disassembly (uncoating) must occur before integration of viral genomic
DNA into the host chromosomes, yet remarkably, the timing and cellular location of …

After cell entry, human immunodeficiency virus type 1 (HIV-1) replication involves reverse
transcription of the RNA genome, nuclear import of the subviral complex without nuclear …

Retroviral infection involves the reverse transcription of the viral RNA genome into DNA,
which is subsequently integrated into the host cell genome. Human immunodeficiency virus …

In a mature, infectious HIV-1 virion, the viral genome is housed within a conical capsid core
made from the viral capsid (CA) protein. The CA protein and the structure into which it …

The early steps of HIV-1 infection, such as uncoating, reverse transcription, nuclear import,
and transport to integration sites are incompletely understood. Here, we imaged nuclear …

HIV-1 replication commences inside the cone-shaped viral capsid, but timing, localization,
and mechanism of uncoating are under debate. We adapted a strategy to visualize …