Renal damage induced by cadmium and its possible therapy by mitochondrial transplantation

EY Hernández-Cruz, I Amador-Martínez… - Chemico-biological …, 2022 - Elsevier
Cadmium (Cd) is one of the most toxic metals without biological function, and its
accumulation in living organisms has been reported. The kidney is a target organ in Cd …

Fighting Parkinson's disease: The return of the mitochondria

K Zambrano, D Barba, K Castillo, L Noboa… - Mitochondrion, 2022 - Elsevier
Parkinson's disease (PD) is the most common neurodegenerative movement disorder,
worldwide. PD neuro-energetically affects the extrapyramidal system, by the progressive …

An overview on mitochondrial‐based therapies in sepsis‐related myocardial dysfunction: mitochondrial transplantation as a promising approach

B Mokhtari, R Yavari, R Badalzadeh… - Canadian Journal of …, 2022 - Wiley Online Library
Sepsis is defined as a life‐threatening organ failure due to dysregulated host response to
infection. Despite current advances in our knowledge about sepsis, it is still considered as a …

Mitochondrial transplantation protects against sepsis-induced myocardial dysfunction by modulating mitochondrial biogenesis and fission/fusion and inflammatory …

B Mokhtari, M Hamidi, R Badalzadeh… - Molecular Biology …, 2023 - Springer
Background Sepsis-induced myocardial dysfunction is associated with worse clinical
outcomes and high mortality, but no effective therapeutic intervention has been explored …

[HTML][HTML] Human umbilical cord mesenchymal stem cell-derived mitochondria (PN-101) attenuate LPS-induced inflammatory responses by inhibiting NFκB signaling …

SH Yu, S Kim, Y Kim, SE Lee, JH Park, G Cho, JC Ha… - BMB …, 2022 - ncbi.nlm.nih.gov
Inflammation is one of the body's natural responses to injury and illness as part of the
healing process. However, persistent inflammation can lead to chronic inflammatory …

Serial change of endotoxin tolerance in a polymicrobial sepsis model

MJ Lee, J Bae, JH Lee, YJ Park, HAR Lee… - International journal of …, 2022 - mdpi.com
Immune suppression is known to occur during sepsis. Endotoxin tolerance is considered a
mechanism of immune suppression in sepsis. However, the timing and serial changes in …

Effects of glucocorticoid therapy on sepsis depend both on the dose of steroids and on the severity and phase of the animal sepsis model

YJ Park, MJ Lee, J Bae, JH Lee, HAR Lee, S Mun… - Life, 2022 - mdpi.com
Steroids are currently being used in sepsis, particularly in septic shock. However, clinical
trials to date have shown contradictory results. This could be attributed to the different patient …

Therapeutic potential of mitochondrial transplantation in modulating immune responses post-cardiac arrest: a narrative review

T Aoki, Y Endo, E Nakamura, CE Kuschner… - Journal of Translational …, 2024 - Springer
Abstract Background Mitochondrial transplantation (MTx) has emerged as a novel
therapeutic strategy, particularly effective in diseases characterized by mitochondrial …

Plant‐derived exosomes extracted from Lycium barbarum L. loaded with isoliquiritigenin to promote spinal cord injury repair based on 3D printed bionic scaffold

Q Wang, K Liu, X Cao, W Rong, W Shi… - Bioengineering & …, 2024 - Wiley Online Library
Plant‐derived exosomes (PEs) possess an array of therapeutic properties, including
antitumor, antiviral, and anti‐inflammatory capabilities. They are also implicated in defensive …

The Effects of Mitochondrial Transplantation on Sepsis Depend on the Type of Cell from Which They Are Isolated

YS Kim, HAR Lee, MJ Lee, YJ Park, S Mun… - International journal of …, 2023 - mdpi.com
Previously, we have shown that mitochondrial transplantation in the sepsis model has
immune modulatory effects. The mitochondrial function could have different characteristics …