Evidence of significant hearing loss during the early days of use of cisplatin as a
chemotherapeutic agent in cancer patients has stimulated research into the causes and …

Cisplatin has dramatically improved the survival rate of cancer patients, but it has also
increased the prevalence of hearing and neurological deficits in this population. Cisplatin …

Purpose The platinum chemotherapy agents cisplatin and carboplatin are widely used in the
treatment of adult and pediatric cancers. Cisplatin causes hearing loss in at least 60% of …

Cisplatin is a widely used chemotherapeutic agent to treat malignant disease. Unfortunately,
ototoxicity occurs in a large percentage of patients treated with higher dose regimens. In …

Cisplatin is a chemotherapeutic agent that is widely used to treat a variety of malignant
tumors. Serious dose-limiting side effects like ototoxicity, nephrotoxicity and neurotoxicity …

Cisplatin is a highly effective antitumor drug generally used in the treatment of solid
malignant tumors. However, cisplatin causes severe side effects such as bone marrow …

Ferroptosis is a recently recognized form of non‐apoptotic cell death caused by an iron‐
dependent accumulation of lipid hydroperoxides, which plays important roles in a wide …

Cisplatin-related ototoxicity is a critical side effect of chemotherapy and can lead to
irreversible hearing loss. This study aimed to assess the potential effect of the DNA …

Cisplatin is an effective drug used in the treatment of many cancers, yet its ototoxic potential
places cancer patients, exposed to this drug, at risk of hearing loss, thus negatively …

Cisplatin is a highly effective chemotherapeutic agent that is widely used to treat solid organ
malignancies. However, serious side effects have been associated with its use, such as …