Background With the rise of large-scale genome sequencing projects, genotyping of
thousands of samples has produced immense variant call format (VCF) files. It is becoming …

Rapid advances in high‐throughput DNA sequencing technologies have enabled large‐
scale whole genome sequencing (WGS) studies. Before performing association analysis …

Whole-genome sequencing projects of millions of subjects contain enormous genotypes,
entailing a huge memory burden and time for computation. Here, we present GBC, a toolkit …

Background: Variant Call Format (VCF) is the standard file format for interchanging genetic
variation data and associated quality control metrics. The usual row-wise encoding of the …

In the last decades, the human genoma analysis for addressing health-care problems, has
widely grown. With the high throughput of biological data and, needing of represent them …

Genozip performs compression of a wide range of genomic data, including widely used
FASTQ, BAM and VCF file formats. Here, we introduce the latest advancement in Genozip …

Abstract When screening abnormal genes [7](such as cancer genes), it is very difficult to
only rely on the experience of bioinformatics scientists, so we usually use deep learning …

In recent years, the development of new technologies has brought down the cost of genome
sequencing by several orders of magnitude. This has ushered in a new era of genomic …