Discoveries have emerged highlighting the complex nature of the interorgan cross-talk
between the kidney and the lung. Vascular rigidity, neurohormonal activation, tissue …

Obstructive sleep apnea (OSA) is characterized by repetitive apnea–hypopnea cycles
during sleep, which are associated with oxygen desaturation and sleep disruption. Up to …

Sporadic amyotrophic lateral sclerosis (ALS) is one of the most devastating neurological
diseases; most patients die within 3 to 4 years after symptom onset. Oxidative stress is a …

The respiratory response to hypoxia in mammals develops from an inhibition of breathing
movements in utero into a sustained increase in ventilation in the adult. This ventilatory …

Rationale: To establish a new approach to investigate the physiological effects of obstructive
sleep apnea (OSA), and to evaluate novel treatments, during a period of continuous positive …

Intermittent hypoxic episodes are typically a consequence of immature respiratory control
and remain a troublesome challenge for the neonatologist. Furthermore, their frequency and …

Background and objective: There has been increasing recognition that obstructive sleep
apnoea (OSA) is associated with incident type 2 diabetes. The aim of this study was to …

In the United States the prevalence of end-stage renal disease (ESRD) reached epidemic
proportions in 2012 with over 600,000 patients being treated. The rates of ESRD among the …

Neurophysiologically, central apnea is due to a temporary failure in the pontomedullary
pacemaker generating breathing rhythm. As a polysomnographic finding, central apneas …

ABSTRACT OSA is increasingly recognized as a major health problem in developed
countries. Obesity is the most common risk factor in OSA and hence, the prevalence of OSA …