The molecular basis of erythrocyte invasion by malaria parasites
Plasmodium species cause malaria by proliferating in human erythrocytes. Invasion of
immunologically privileged erythrocytes provides a relatively protective niche as well as …
immunologically privileged erythrocytes provides a relatively protective niche as well as …
Plasmodium Egress Across the Parasite Life Cycle
JD Dvorin, DE Goldberg - Annual review of microbiology, 2022 - annualreviews.org
Human malaria, caused by infection with Plasmodium parasites, remains one of the most
important global public health problems, with the World Health Organization reporting more …
important global public health problems, with the World Health Organization reporting more …
Artemisinin-resistant K13 mutations rewire Plasmodium falciparum's intra-erythrocytic metabolic program to enhance survival
The emergence and spread of artemisinin resistance, driven by mutations in Plasmodium
falciparum K13, has compromised antimalarial efficacy and threatens the global malaria …
falciparum K13, has compromised antimalarial efficacy and threatens the global malaria …
Plasma Membrane Association by N-Acylation Governs PKG Function in Toxoplasma gondii
Cyclic GMP (cGMP)-dependent protein kinase (protein kinase G [PKG]) is essential for
microneme secretion, motility, invasion, and egress in apicomplexan parasites, However …
microneme secretion, motility, invasion, and egress in apicomplexan parasites, However …
A potent series targeting the malarial cGMP-dependent protein kinase clears infection and blocks transmission
DA Baker, LB Stewart, JM Large, PW Bowyer… - Nature …, 2017 - nature.com
To combat drug resistance, new chemical entities are urgently required for use in next
generation anti-malarial combinations. We report here the results of a medicinal chemistry …
generation anti-malarial combinations. We report here the results of a medicinal chemistry …
Temporal and thermal profiling of the Toxoplasma proteome implicates parasite Protein Phosphatase 1 in the regulation of Ca2+-responsive pathways
AL Herneisen, ZH Li, AW Chan, SNJ Moreno… - Elife, 2022 - elifesciences.org
Apicomplexan parasites cause persistent mortality and morbidity worldwide through
diseases including malaria, toxoplasmosis, and cryptosporidiosis. Ca 2+ signaling pathways …
diseases including malaria, toxoplasmosis, and cryptosporidiosis. Ca 2+ signaling pathways …
The structure of the core NuRD repression complex provides insights into its interaction with chromatin
The NuRD complex is a multi-protein transcriptional corepressor that couples histone
deacetylase and ATP-dependent chromatin remodelling activities. The complex regulates …
deacetylase and ATP-dependent chromatin remodelling activities. The complex regulates …
Ca2+ signals critical for egress and gametogenesis in malaria parasites depend on a multipass membrane protein that interacts with PKG
AC Balestra, K Koussis, N Klages, SA Howell… - Science …, 2021 - science.org
Calcium signaling regulated by the cGMP-dependent protein kinase (PKG) controls key life
cycle transitions in the malaria parasite. However, how calcium is mobilized from …
cycle transitions in the malaria parasite. However, how calcium is mobilized from …
PfCDPK1 mediated signaling in erythrocytic stages of Plasmodium falciparum
Abstract Calcium Dependent Protein Kinases are key effectors of calcium signaling in
malaria parasite. PfCDPK1 is critical for asexual development of Plasmodium falciparum, but …
malaria parasite. PfCDPK1 is critical for asexual development of Plasmodium falciparum, but …
Targeting malaria parasite invasion of red blood cells as an antimalarial strategy
AL Burns, MG Dans, JM Balbin… - FEMS microbiology …, 2019 - academic.oup.com
Plasmodium spp. parasites that cause malaria disease remain a significant global-health
burden. With the spread of parasites resistant to artemisinin combination therapies in …
burden. With the spread of parasites resistant to artemisinin combination therapies in …