Itaconate and itaconate derivatives target JAK1 to suppress alternative activation of macrophages
The Krebs cycle-derived metabolite itaconate and its derivatives suppress the inflammatory
response in pro-inflammatory" M1" macrophages. However, alternatively activated" M2" …
response in pro-inflammatory" M1" macrophages. However, alternatively activated" M2" …
Neutrophils resist ferroptosis and promote breast cancer metastasis through aconitate decarboxylase 1
Metastasis causes breast cancer-related mortality. Tumor-infiltrating neutrophils (TINs) inflict
immunosuppression and promote metastasis. Therapeutic debilitation of TINs may enhance …
immunosuppression and promote metastasis. Therapeutic debilitation of TINs may enhance …
Metabolic messengers: itaconate
AF McGettrick, LA Bourner, FC Dorsey, LAJ O'Neill - Nature Metabolism, 2024 - nature.com
The metabolite itaconate has emerged as an important immunoregulator with roles in
antibacterial defence, inhibition of inflammation and, more recently, as an inhibitory factor in …
antibacterial defence, inhibition of inflammation and, more recently, as an inhibitory factor in …
Itaconate suppresses atherosclerosis by activating a Nrf2-dependent antiinflammatory response in macrophages in mice
Itaconate has emerged as a critical immunoregulatory metabolite. Here, we examined the
therapeutic potential of itaconate in atherosclerosis. We found that both itaconate and the …
therapeutic potential of itaconate in atherosclerosis. We found that both itaconate and the …
ABCG2 is an itaconate exporter that limits antibacterial innate immunity by alleviating TFEB-dependent lysosomal biogenesis
Itaconate is a metabolite that synthesized from cis-aconitate in mitochondria and transported
into the cytosol to exert multiple regulatory effects in macrophages. However, the …
into the cytosol to exert multiple regulatory effects in macrophages. However, the …
[HTML][HTML] Mild COVID-19 imprints a long-term inflammatory eicosanoid-and chemokine memory in monocyte-derived macrophages
S Bohnacker, F Hartung, F Henkel, A Quaranta… - Mucosal …, 2022 - Elsevier
Monocyte-derived macrophages (MDM) drive the inflammatory response to severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2) and they are a major source of …
respiratory syndrome coronavirus 2 (SARS-CoV-2) and they are a major source of …
Metabolic pathways in immune senescence and inflammaging: Novel therapeutic strategy for chronic inflammatory lung diseases. An EAACI position paper from the …
F Roth‐Walter, IM Adcock, C Benito‐Villalvilla… - Allergy, 2024 - Wiley Online Library
The accumulation of senescent cells drives inflammaging and increases morbidity of chronic
inflammatory lung diseases. Immune responses are built upon dynamic changes in cell …
inflammatory lung diseases. Immune responses are built upon dynamic changes in cell …
Itaconate impairs immune control of Plasmodium by enhancing mtDNA-mediated PD-L1 expression in monocyte-derived dendritic cells
Severe forms of malaria are associated with systemic inflammation and host metabolism
disorders; however, the interplay between these outcomes is poorly understood. Using a …
disorders; however, the interplay between these outcomes is poorly understood. Using a …
[HTML][HTML] Itaconate promotes a wound resolving phenotype in pro-inflammatory macrophages
Pathological conditions associated with dysfunctional wound healing are characterized by
impaired remodelling of extracellular matrix (ECM), increased macrophage infiltration, and …
impaired remodelling of extracellular matrix (ECM), increased macrophage infiltration, and …
[HTML][HTML] AMPK integrates metabolite and kinase-based immunometabolic control in macrophages
Objective Previous mechanistic studies on immunometabolism have focused on metabolite-
based paradigms of regulation, such as itaconate. Here, we, demonstrate integration of …
based paradigms of regulation, such as itaconate. Here, we, demonstrate integration of …