Mathematical modelling approaches have become increasingly abundant in cancer
research. The complexity of cancer is well suited to quantitative approaches as it provides …

Over the past decade, whole genome sequencing and other'omics' technologies have
defined pathogenic driver mutations to which tumor cells are addicted. Such addictions …

The fight against cancer has drawn researchers from a wide variety of disciplines, ranging
from molecular biology to physics, but the perspective of an ecological theorist has been …

The treatment of patients with advanced non–small cell lung cancer (NSCLC) harboring
chromosomal rearrangements of anaplastic lymphoma kinase (ALK) has been …

Acquired drug resistance is a major limitation for the successful treatment of cancer.
Resistance can emerge due to a variety of reasons including host environmental factors as …

The clinical efficacy of EGF receptor (EGFR) kinase inhibitors gefitinib and erlotinib is limited
by the development of drug resistance. The most common mechanism of drug resistance is …

Targeted agents have improved the efficacy of chemotherapy for cancer patients, however,
there remains a lack of understanding of how these therapies affect the unsuspecting …

Therapeutic resistance arises as a result of evolutionary processes driven by dynamic
feedback between a heterogeneous cell population and environmental selective pressures …

Purpose Drug resistance is a major impediment to the success of cancer treatment.
Resistance is typically thought to arise from random genetic mutations, after which mutated …

The role of genetic mutations in cancer is indisputable: They are a key source of tumor
heterogeneity and drive its evolution to malignancy. But, the success of these new mutant …