Polymorphism of human cytochrome P450 enzymes and its clinical impact
Pharmacogenetics is the study of how interindividual variations in the DNA sequence of
specific genes affect drug response. This article highlights current pharmacogenetic …
specific genes affect drug response. This article highlights current pharmacogenetic …
The cytochrome P450 superfamily: biochemistry, evolution and drug metabolism in humans
PB Danielson - Current drug metabolism, 2002 - ingentaconnect.com
Cytochrome P450s comprise a superfamily of heme-thiolate proteins named for the spectral
absorbance peak of their carbon-monoxide-bound species at 450 nm. Having been found in …
absorbance peak of their carbon-monoxide-bound species at 450 nm. Having been found in …
Summary of information on human CYP enzymes: human P450 metabolism data
S Rendic - Drug metabolism reviews, 2002 - Taylor & Francis
This chapter is an update of the data on substrates, reactions, inducers, and inhibitors of
human CYP enzymes published previously by Rendic and DiCarlo Citation 1a, Citation 1b …
human CYP enzymes published previously by Rendic and DiCarlo Citation 1a, Citation 1b …
Cytochrome P4502C9: an enzyme of major importance in human drug metabolism
JO Miners, DJ Birkett - British journal of clinical pharmacology, 1998 - Wiley Online Library
Accumulating evidence indicates that CYP2C9 ranks amongst the most important drug
metabolizing enzymes in humans. Substrates for CYP2C9 include fluoxetine, losartan …
metabolizing enzymes in humans. Substrates for CYP2C9 include fluoxetine, losartan …
Inhibition and induction of human cytochrome P450 enzymes: current status
Variability of drug metabolism, especially that of the most important phase I enzymes or
cytochrome P450 (CYP) enzymes, is an important complicating factor in many areas of …
cytochrome P450 (CYP) enzymes, is an important complicating factor in many areas of …
Herb-drug interactions: a literature review
Herbs are often administered in combination with therapeutic drugs, raising the potential of
herb-drug interactions. An extensive review of the literature identified reported herb-drug …
herb-drug interactions. An extensive review of the literature identified reported herb-drug …
Hydroxylation of warfarin by human cDNA-expressed cytochrome P-450: a role for P-4502C9 in the etiology of (S)-warfarin-drug interactions
AE Rettie, KR Korzekwa, KL Kunze… - Chemical research in …, 1992 - ACS Publications
Previous kinetic studies have identified a high-affinity (S)-warfarin 7-hydroxylase present in
human liver microsomes which appears to be responsible for the termination of warfarin's …
human liver microsomes which appears to be responsible for the termination of warfarin's …
Cytochrome P450 2C9-CYP2C9
D Van Booven, S Marsh, H McLeod… - Pharmacogenetics …, 2010 - journals.lww.com
CYP2C9 is a phase I drug-metabolizing cytochrome P450 (CYP450) enzyme isoform that
plays a major role in the oxidation of both xenobiotic and endogenous compounds. Gray et …
plays a major role in the oxidation of both xenobiotic and endogenous compounds. Gray et …
Effects of the antifungal agents on oxidative drug metabolism: clinical relevance
K Venkatakrishnan, LL Von Moltke… - Clinical …, 2000 - Springer
This article reviews the metabolic pharmacokinetic drug-drug interactions with the systemic
antifungal agents: the azoles ketoconazole, miconazole, itraconazole and fluconazole, the …
antifungal agents: the azoles ketoconazole, miconazole, itraconazole and fluconazole, the …
Herbal modulation of P‐glycoprotein
P‐glycoprotein (Pgp) is a 170 kDa phosphorylated glycoprotein encoded by human MDR1
gene. It is responsible for the systemic disposition of numerous structurally and …
gene. It is responsible for the systemic disposition of numerous structurally and …