Pharmacogenetics is the study of how interindividual variations in the DNA sequence of
specific genes affect drug response. This article highlights current pharmacogenetic …

Cytochrome P450s comprise a superfamily of heme-thiolate proteins named for the spectral
absorbance peak of their carbon-monoxide-bound species at 450 nm. Having been found in …

This chapter is an update of the data on substrates, reactions, inducers, and inhibitors of
human CYP enzymes published previously by Rendic and DiCarlo Citation 1a, Citation 1b …

Accumulating evidence indicates that CYP2C9 ranks amongst the most important drug
metabolizing enzymes in humans. Substrates for CYP2C9 include fluoxetine, losartan …

Variability of drug metabolism, especially that of the most important phase I enzymes or
cytochrome P450 (CYP) enzymes, is an important complicating factor in many areas of …

Herbs are often administered in combination with therapeutic drugs, raising the potential of
herb-drug interactions. An extensive review of the literature identified reported herb-drug …

Previous kinetic studies have identified a high-affinity (S)-warfarin 7-hydroxylase present in
human liver microsomes which appears to be responsible for the termination of warfarin's …

CYP2C9 is a phase I drug-metabolizing cytochrome P450 (CYP450) enzyme isoform that
plays a major role in the oxidation of both xenobiotic and endogenous compounds. Gray et …

This article reviews the metabolic pharmacokinetic drug-drug interactions with the systemic
antifungal agents: the azoles ketoconazole, miconazole, itraconazole and fluconazole, the …

P‐glycoprotein (Pgp) is a 170 kDa phosphorylated glycoprotein encoded by human MDR1
gene. It is responsible for the systemic disposition of numerous structurally and …