Mechanisms and physiological implications of cooperative gating of clustered ion channels
Ion channels play a central role in the regulation of nearly every cellular process. Dating
back to the classic 1952 Hodgkin–Huxley model of the generation of the action potential, ion …
back to the classic 1952 Hodgkin–Huxley model of the generation of the action potential, ion …
Nanoscale organization, regulation, and dynamic reorganization of cardiac calcium channels
RE Dixon - Frontiers in physiology, 2022 - frontiersin.org
The architectural specializations and targeted delivery pathways of cardiomyocytes ensure
that L-type Ca2+ channels (CaV1. 2) are concentrated on the t-tubule sarcolemma within …
that L-type Ca2+ channels (CaV1. 2) are concentrated on the t-tubule sarcolemma within …
STIM1-dependent peripheral coupling governs the contractility of vascular smooth muscle cells
Peripheral coupling between the sarcoplasmic reticulum (SR) and plasma membrane (PM)
forms signaling complexes that regulate the membrane potential and contractility of vascular …
forms signaling complexes that regulate the membrane potential and contractility of vascular …
Kv2. 1 mediates spatial and functional coupling of L-type calcium channels and ryanodine receptors in mammalian neurons
NC Vierra, M Kirmiz, D van der List, LF Santana… - Elife, 2019 - elifesciences.org
The voltage-gated K+ channel Kv2. 1 serves a major structural role in the soma and
proximal dendrites of mammalian brain neurons, tethering the plasma membrane (PM) to …
proximal dendrites of mammalian brain neurons, tethering the plasma membrane (PM) to …
Cardiac ryanodine receptor distribution is dynamic and changed by auxiliary proteins and post-translational modification
The effects of the immunophilins, FKBP12 and FKBP12. 6, and phosphorylation on type II
ryanodine receptor (RyR2) arrangement and function were examined using correlation …
ryanodine receptor (RyR2) arrangement and function were examined using correlation …
[HTML][HTML] DNA origami nanorulers and emerging reference structures
The DNA origami technique itself is considered a milestone of DNA nanotechnology and
DNA origami nanorulers represent the first widespread application of this technique. DNA …
DNA origami nanorulers represent the first widespread application of this technique. DNA …
Cardiac multiscale bioimaging: from nano-through micro-to mesoscales
Cardiac multiscale bioimaging is an emerging field that aims to provide a comprehensive
understanding of the heart and its functions at various levels, from the molecular to the entire …
understanding of the heart and its functions at various levels, from the molecular to the entire …
Cerebral arteriolar and neurovascular dysfunction after chemically induced menopause in mice
JA Blackwell, JF Silva, EM Louis… - American Journal …, 2022 - journals.physiology.org
Cognitive decline is linked to decreased cerebral blood flow, particularly in women after
menopause. Impaired cerebrovascular function precedes the onset of dementia, possibly …
menopause. Impaired cerebrovascular function precedes the onset of dementia, possibly …
Three-dimensional and chemical mapping of intracellular signaling nanodomains in health and disease with enhanced expansion microscopy
TMD Sheard, ME Hurley, J Colyer, E White… - ACS …, 2019 - ACS Publications
Nanodomains are intracellular foci which transduce signals between major cellular
compartments. One of the most ubiquitous signal transducers, the ryanodine receptor (RyR) …
compartments. One of the most ubiquitous signal transducers, the ryanodine receptor (RyR) …
Functionally linked potassium channel activity in cerebral endothelial and smooth muscle cells is compromised in Alzheimer's disease
JL Taylor, HAT Pritchard, KR Walsh… - Proceedings of the …, 2022 - National Acad Sciences
The brain microcirculation is increasingly viewed as a potential target for disease-modifying
drugs in the treatment of Alzheimer's disease patients, reflecting a growing appreciation of …
drugs in the treatment of Alzheimer's disease patients, reflecting a growing appreciation of …