Covalent small-molecule inhibitors of SARS-CoV-2 Mpro: Insights into their design, classification, biological activity, and binding interactions

AM Shawky, FA Almalki, HA Alzahrani… - European Journal of …, 2024 - Elsevier
Since 2020, many compounds have been investigated for their potential use in the treatment
of SARS-CoV-2 infection. Among these agents, a huge number of natural products and FDA …

Safety and efficacy of new generation azole antifungals in the management of recalcitrant superficial fungal infections and onychomycosis

AK Gupta, M Talukder, A Shemer… - Expert Review of Anti …, 2024 - Taylor & Francis
Introduction Terbinafine is considered the gold standard for treating skin fungal infections
and onychomycosis. However, recent reports suggest that dermatophytes are developing …

Systemic absorption and safety of topical terbinafine hydrochloride 10% solution (MOB015B): a phase 1 maximal usage trial in patients with moderate-to-severe …

A Tavakkol, JC DuBois, AK Gupta - Antimicrobial agents and …, 2024 - journals.asm.org
Topical antifungals may be considered to treat onychomycosis with minimal risk of systemic
side effects. In this study, we assess the safety, tolerability, systemic exposure, and …

Terbinafine in acrylic polymer for the treatment of onychomycosis in hemodialysis patients: a phase II clinical trial

JMQB Bersano, MG Cordeiro, JM Sciani… - Frontiers in …, 2024 - frontiersin.org
Introduction Onychomycosis is a nail infection caused by dermatophyte fungi, non-
dermatophyte fungi, and yeast. Patients with chronic kidney disease on dialysis are part of …

In vitro Evaluation of Antifungal Activity of Terbinafine Nano Form against Yeast Organism Isolated in Thumby Labs Ajman.

AL Osman, S Jacob, A Mohammed… - Journal of Pure & …, 2024 - search.ebscohost.com
The goal of this study is to evaluate the antifungal activity of terbinafine in its nano form
against yeast organisms in vitro and compare its effectiveness to the normal form of …