The free energy landscape concept that describes enzymes as an ensemble of differently
populated conformational sub-states in dynamic equilibrium is key for evaluating enzyme …

The computational study of enantioselective reactions is a challenging task that requires
high accuracy, as very small energy differences have to be reproduced. Quantum chemical …

Diaryl ketones are important building blocks for synthesizing pharmaceuticals and are
generally regarded as “difficult-to-reduce” ketones due to the large steric hindrance of their …

Biocatalysis is increasingly replacing traditional methods of manufacturing fine chemicals
due to its green, mild, and highly selective nature, but biocatalysts, such as enzymes, are …

Biocatalyzed asymmetric reduction of ketones is one of the most cost-effective and
environmentally friendly approaches for preparing chiral alcohols. However, few natural …

Alcohol dehydrogenases (ADHs) are an important type of enzyme that have significant
applications as biocatalysts. Secondary ADHs from Thermoanaerobacter …

Directed evolution of enzymes for the asymmetric reduction of prochiral ketones to produce
enantio‐pure secondary alcohols is particularly attractive in organic synthesis. Loops …

Short-chain dehydrogenase/reductase (SDR) acts as a biocatalyst in the synthesis of chiral
alcohols with high optical purity. Herein, we achieved immobilization via crosslinking on …

Flow biocatalysis involving oxidoreductase is limited by the difficulty in recycling expensive
cofactors. In this study, an enzyme‐rich hydrogel monolithic microreactor was developed via …

Alcohol Dehydrogenase (ADH) enzymes catalyse the reversible reduction of prochiral
ketones to the corresponding alcohols. These enzymes present two differently shaped active …