Advances in mesenchymal stem cell therapy for immune and inflammatory diseases: Use of cell-free products and human pluripotent stem cell-derived mesenchymal …

LT Wang, KJ Liu, HK Sytwu, ML Yen… - Stem cells translational …, 2021 - academic.oup.com
Mesenchymal stem cell therapy (MSCT) for immune and inflammatory diseases continues to
be popular based on progressive accumulation of preclinical mechanistic evidence. This …

Stem cell therapies for progressive multiple sclerosis

JA Smith, AM Nicaise, RB Ionescu, R Hamel… - Frontiers in cell and …, 2021 - frontiersin.org
Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system
characterized by demyelination and axonal degeneration. MS patients typically present with …

Neural stem cells derived from primitive mesenchymal stem cells reversed disease symptoms and promoted neurogenesis in an experimental autoimmune …

C Brown, C McKee, S Halassy, S Kojan… - Stem Cell Research & …, 2021 - Springer
Background Multiple sclerosis (MS) is an autoimmune inflammatory disease of the central
nervous system (CNS). MS affects millions of people and causes a great economic and …

Re-establishing immune tolerance in multiple sclerosis: focusing on novel mechanisms of mesenchymal stem cell regulation of Th17/Treg balance

H Hu, H Li, R Li, P Liu, H Liu - Journal of Translational Medicine, 2024 - Springer
Abstract The T-helper 17 (Th17) cell and regulatory T cell (Treg) axis plays a crucial role in
the development of multiple sclerosis (MS), which is regarded as an immune imbalance …

[HTML][HTML] Understanding the spectrum of non-motor symptoms in multiple sclerosis: insights from animal models

PDE Weerasinghe-Mudiyanselage… - Neural Regeneration …, 2024 - journals.lww.com
Multiple sclerosis is a chronic autoimmune disease of the central nervous system and is
generally considered to be a non-traumatic, physically debilitating neurological disorder. In …

Made to measure: patient-tailored treatment of multiple sclerosis using cell-based therapies

I Wens, I Janssens, J Derdelinckx, M Meena… - International journal of …, 2021 - mdpi.com
Currently, there is still no cure for multiple sclerosis (MS), which is an autoimmune and
neurodegenerative disease of the central nervous system. Treatment options predominantly …

The Complementary Roles of Neurological and Musculoskeletal Physical Therapy and Regenerative Medicine: A Comprehensive Review

M Mureed, A Fatima, T Sattar, S Aiman Batool, A Zahid… - Medicina, 2024 - mdpi.com
Regenerative medicine, encompassing various therapeutic approaches aimed at tissue
repair and regeneration, has emerged as a promising field in the realm of physical therapy …

Current status of mesenchymal stem/stromal cells for treatment of neurological diseases

MBP Soares, RGJ Gonçalves, JF Vasques… - Frontiers in Molecular …, 2022 - frontiersin.org
Neurological disorders include a wide spectrum of clinical conditions affecting the central
and peripheral nervous systems. For these conditions, which affect hundreds of millions of …

Human Umbilical Cord–Derived Mesenchymal Stem Cells in the Treatment of Multiple Sclerosis Patients: Phase I/II Dose-Finding Clinical Study

F Jamali, M Aldughmi, S Atiani… - Cell …, 2024 - journals.sagepub.com
Multiple sclerosis (MS) is a chronic neuro-inflammatory disease resulting in disabilities that
negatively impact patients' life quality. While current treatment options do not reverse the …

Mesenchymal stem cells and their derived exosomes in multiple sclerosis disease: from paper to practice

SH Hamidi, N Etebar, M Rahimzadegan, A Zali… - Molecular and Cellular …, 2024 - Springer
Multiple sclerosis (MS) is a chronic neurodegenerative, inflammatory, and demyelinating
disease of the central nervous system (CNS). Current medicines are not sufficient to control …