Genetics and epigenetics in asthma

P Ntontsi, A Photiades, E Zervas, G Xanthou… - International journal of …, 2021 - mdpi.com
Asthma is one of the most common respiratory disease that affects both children and adults
worldwide, with diverse phenotypes and underlying pathogenetic mechanisms poorly …

Targeting cell signaling in allergic asthma

SS Athari - Signal transduction and targeted therapy, 2019 - nature.com
Asthma is chronic inflammation of the airways characterized by airway hyper-
responsiveness, wheezing, cough, and dyspnea. Asthma affects> 350 million people …

Spotlight on microRNAs in allergy and asthma

J Weidner, S Bartel, A Kılıç, UM Zissler, H Renz… - Allergy, 2021 - Wiley Online Library
In past 10 years, microRNAs (miRNAs) have gained scientific attention due to their
importance in the pathophysiology of allergic diseases and their potential as biomarkers in …

Genetics and epigenetics in allergic rhinitis

BY Choi, M Han, JW Kwak, TH Kim - Genes, 2021 - mdpi.com
The pathogenesis of allergic rhinitis is associated with genetic, environmental, and
epigenetic factors. Genotyping of single nucleotide polymorphisms (SNPs) is an advanced …

Diagnostic, functional, and therapeutic roles of microRNA in allergic diseases

TX Lu, ME Rothenberg - Journal of Allergy and Clinical Immunology, 2013 - Elsevier
Allergic inflammation is accompanied by the coordinated expression of a myriad of genes
and proteins that initiate, sustain, and propagate immune responses and tissue remodeling …

The roles of miRNAs as potential biomarkers in lung diseases

SD Alipoor, IM Adcock, J Garssen, E Mortaz… - European journal of …, 2016 - Elsevier
MicroRNAs (miRNAs) are small non-coding RNAs which can act as master regulators of
gene expression, modulate almost all biological process and are essential for maintaining …

Dnmt3a restrains mast cell inflammatory responses

C Leoni, S Montagner, A Rinaldi… - Proceedings of the …, 2017 - National Acad Sciences
DNA methylation and specifically the DNA methyltransferase enzyme DNMT3A are involved
in the pathogenesis of a variety of hematological diseases and in regulating the function of …

Role of microRNAs in lung development and pulmonary diseases

R Sessa, A Hata - Pulmonary circulation, 2013 - journals.sagepub.com
MicroRNAs (miRNAs) are a class of small noncoding RNA which exert post-transcriptional
gene regulation activity by targeting messenger RNAs. miRNAs have been found to be …

Vesicular trafficking and signaling for cytokine and chemokine secretion in mast cells

U Blank, IK Madera-Salcedo, L Danelli… - Frontiers in …, 2014 - frontiersin.org
Upon activation mast cells (MCs) secrete numerous inflammatory compounds stored in their
cytoplasmic secretory granules by a process called anaphylactic degranulation, which is …

MicroRNA regulation of allergic inflammation and asthma

HH Pua, KM Ansel - Current Opinion in Immunology, 2015 - Elsevier
Highlights•miRNAs regulate allergic inflammation and allergic responses.•miRNAs act
coordinately through target gene networks.•miRNAs impact diverse cellular functions in type …