Organoids are simple tissue-engineered cell-based in vitro models that recapitulate many
aspects of the complex structure and function of the corresponding in vivo tissue. They can …

Tumor microenvironment (TME) is a specialized ecosystem of host components, designed
by tumor cells for successful development and metastasis of tumor. With the advent of 3D …

The historical reliance of biological research on the use of animal models has sometimes
made it challenging to address questions that are specific to the understanding of human …

Adult stem cell–based organoid technology is a versatile tool for the generation and long-
term maintenance of near-native 3D epithelial tissues in vitro. The generation of cancer …

The distal lung contains terminal bronchioles and alveoli that facilitate gas exchange. Three-
dimensional in vitro human distal lung culture systems would strongly facilitate the …

The intestinal barrier is essential in human health and constitutes the interface between the
outside and the internal milieu of the body. A functional intestinal barrier allows absorption of …

Abstract Three-dimensional (3D) stem cell culture systems have attracted considerable
attention as a way to better mimic the complex interactions between individual cells and the …

Recent studies have demonstrated an array of stem cell–derived, self-organizing miniature
organs, termed organoids, that replicate the key structural and functional characteristics of …

Tissue and organ biology are very challenging to study in mammals, and progress can be
hindered, particularly in humans, by sample accessibility and ethical concerns. However …

Constant remodeling of tight junctions to regulate trans-epithelial permeability is essential in
maintaining intestinal barrier functions and thus preventing diffusion of small molecules and …