Biomolecular condensates: new opportunities for drug discovery and RNA therapeutics

BA Conti, M Oppikofer - Trends in Pharmacological Sciences, 2022 - cell.com
Biomolecular condensates organize cellular functions in the absence of membranes. These
membraneless organelles can form through liquid–liquid phase separation coalescing RNA …

[HTML][HTML] Stress granules dynamics: benefits in cancer

JI Lee, S Namkoong - BMB reports, 2022 - ncbi.nlm.nih.gov
Stress granules (SGs) are stress-induced subcellular compartments, which carry out a
particular function to cope with stress. These granules protect cells from stress-related …

Regulation of cellular ribonucleoprotein granules: from assembly to degradation via post-translational modification

P Jeon, HJ Ham, S Park, JA Lee - Cells, 2022 - mdpi.com
Cells possess membraneless ribonucleoprotein (RNP) granules, including stress granules,
processing bodies, Cajal bodies, or paraspeckles, that play physiological or pathological …

Role of stress granules in tumorigenesis and cancer therapy

T Li, Z Zeng, C Fan, W Xiong - … et Biophysica Acta (BBA)-Reviews on …, 2023 - Elsevier
Stress granules (SGs) are membrane-less organelles that cell forms via liquid-liquid phase
separation (LLPS) under stress conditions such as oxidative stress, ER stress, heat shock …

Act1 drives chemoresistance via regulation of antioxidant RNA metabolism and redox homeostasis

L Hong, T Herjan, X Chen, LL Zagore, K Bulek… - Journal of Experimental …, 2024 - rupress.org
The IL-17 receptor adaptor molecule Act1, an RNA-binding protein, plays a critical role in IL-
17–mediated cancer progression. Here, we report a novel mechanism of how IL-17/Act1 …

Diverse roles of biomolecular condensation in eukaryotic translational regulation

Y Zhang, JY Kang, M Liu, Y Huang - RNA biology, 2023 - Taylor & Francis
Biomolecular condensates, forming membrane-less organelles, orchestrate the sub-cellular
compartment to execute designated biological processes. An increasing body of evidence …

Stress granule-mediated sequestration of EGR1 mRNAs correlates with lomustine-induced cell death prevention

M Leśniczak-Staszak, P Pietras… - Journal of Cell …, 2024 - journals.biologists.com
Some chemotherapy drugs modulate the formation of stress granules (SGs), which are RNA-
containing cytoplasmic foci contributing to stress response pathways. How SGs …

Nanodrugs based on co-delivery strategies to combat cisplatin resistance

Q Wang, H Li, T Wu, B Yu, H Cong, Y Shen - Journal of Controlled Release, 2024 - Elsevier
Cisplatin (CDDP), as a broad-spectrum anticancer drug, is able to bind to DNA and inhibit
cell division. Despite the widespread use of cisplatin since its discovery, cisplatin resistance …

DCAF7 acts as a scaffold to recruit USP10 for G3BP1 deubiquitylation and facilitates chemoresistance and metastasis in nasopharyngeal carcinoma

QJ Li, XL Fang, YQ Li, JY Lin, CL Huang… - Advanced …, 2024 - Wiley Online Library
Despite docetaxel combined with cisplatin and 5‐fluorouracil (TPF) being the established
treatment for advanced nasopharyngeal carcinoma (NPC), there are patients who do not …

[HTML][HTML] Multiple roles of arsenic compounds in phase separation and membraneless organelles formation determine their therapeutic efficacy in tumors

M Qu, Q He, H Bao, X Ji, T Shen, MQ Barkat… - Journal of …, 2024 - Elsevier
Arsenic compounds are widely used for the therapeutic intervention of multiple diseases.
Ancient pharmacologists discovered the medicinal utility of such highly toxic substances …