The pivotal role of the placenta in normal and pathological pregnancies: a focus on preeclampsia, fetal growth restriction, and maternal chronic venous disease

MA Ortega, O Fraile-Martínez, C García-Montero… - Cells, 2022 - mdpi.com
The placenta is a central structure in pregnancy and has pleiotropic functions. This organ
grows incredibly rapidly during this period, acting as a mastermind behind different fetal and …

Haemolytic uraemic syndrome

M Michael, A Bagga, SE Sartain, RJH Smith - The Lancet, 2022 - thelancet.com
Haemolytic uraemic syndrome (HUS) is a heterogeneous group of diseases that result in a
common pathology, thrombotic microangiopathy, which is classically characterised by the …

[HTML][HTML] COVID-19 and preeclampsia: overlapping features in pregnancy

R Sathiya, J Rajendran, S Sumathi - … Maimonides medical journal, 2022 - ncbi.nlm.nih.gov
Abstract Coronavirus disease 2019 (COVID-19) is a global respiratory disease with unique
features that have placed all medical professionals in an alarming situation. Preeclampsia is …

The relationship between obesity and pre-eclampsia: incidental risks and identification of potential biomarkers for pre-eclampsia

T Abraham, AMP Romani - Cells, 2022 - mdpi.com
Obesity has been steadily increasing over the past decade in the US and worldwide. Since
1975, the prevalence of obesity has increased by 2% per decade, unabated despite new …

Role of microRNAs in trophoblast invasion and spiral artery remodeling: implications for preeclampsia

H Hayder, Y Shan, Y Chen, JA O'Brien… - Frontiers in Cell and …, 2022 - frontiersin.org
It is now well-established that microRNAs (miRNAs) are important regulators of gene
expression. The role of miRNAs in placental development and trophoblast function is …

Blood biomarkers to predict the onset of pre-eclampsia: A systematic review and meta-analysis

M Danielli, RC Thomas, CL Gillies, J Hu, K Khunti… - Heliyon, 2022 - cell.com
Pre-eclampsia is one of the most common pregnancy complications, and a major cause of
fetal and maternal morbidity and mortality globally. Diagnosis currently takes place in the …

The Current Role of the sFlt-1/PlGF Ratio and the Uterine–Umbilical–Cerebral Doppler Ultrasound in Predicting and Monitoring Hypertensive Disorders of Pregnancy …

CN Chirilă, C Mărginean, PM Chirilă, ML Gliga - Children, 2023 - mdpi.com
Regarding the hypertensive disorders of pregnancy, pre-eclampsia (PE) remains one of the
leading causes of severe and life-threatening maternal and fetal complications. Screening of …

[HTML][HTML] Extracellular vesicles and their miRNA contents counterbalance the pro-inflammatory effect of air pollution during physiological pregnancy: A focus on …

L Ferrari, S Iodice, L Cantone, G Solazzo, L Dioni… - Environment …, 2022 - Elsevier
The impact of exposure to respirable particulate matter (PM) during pregnancy is a growing
concern, as several studies have associated increased risks of adverse pregnancy and birth …

Angiogenic imbalance and inflammatory biomarkers in the prediction of hypertension as well as obstetric and perinatal complications in women with gestational …

A Lara-Barea, B Sánchez-Lechuga… - Journal of Clinical …, 2022 - mdpi.com
Gestational diabetes mellitus (GDM) increases the risk of hypertensive disorders of
pregnancy (HDP). We aimed to analyze the altered inflammatory markers and angiogenic …

Clinical validation of the sFlt-1: PlGF ratio as a biomarker for preeclampsia diagnosis in a high-risk obstetrics unit

JJ Miller, V Higgins, N Melamed… - The Journal of …, 2023 - academic.oup.com
Background Preeclampsia is a multisystem disorder defined by new onset of hypertension
with proteinuria after 20 weeks gestation. In part due to dysregulation of pro-angiogenic …