Indentation plasticity and fracture studies of organic crystals

S Mannepalli, KSRN Mangalampalli - Crystals, 2017 - mdpi.com
This review article summarizes the recent advances in measuring and understanding the
indentation-induced plastic deformation and fracture behavior of single crystals of a wide …

The relationship among tensile strength, Young's modulus, and indentation hardness of pharmaceutical compacts

WJ Sun, S Kothari, CC Sun - Powder Technology, 2018 - Elsevier
Mechanical properties of pharmaceutical materials, eg, Young's modulus (E), indentation
hardness (H), and tensile strength (σ t), play an important role in powder compaction …

Application of instrumented nanoindentation in preformulation studies of pharmaceutical active ingredients and excipients

M Egart, B Janković, S Srčič - Acta Pharmaceutica, 2016 - hrcak.srce.hr
Sažetak Nanoindentation allows quantitative determination of a material's response to stress
such as elastic and plastic deformation or fracture tendency. Key instruments that have …

Expedited development of a high dose orally disintegrating metformin tablet enabled by sweet salt formation with acesulfame

C Wang, S Hu, CC Sun - International journal of pharmaceutics, 2017 - Elsevier
Salt formation has been extensively used to improve drug properties, including solubility,
stability and mechanical properties. A sweet salt of metformin with acesulfame, prepared …

层级孔喷涂粉末构筑及新一代长寿命热障涂层材料的研究进展.

郭芳威, 张瑞吉, 邢辰, 蔡黄越… - Journal of …, 2023 - search.ebscohost.com
广泛应用于航空发动机和地面燃气轮机中的热障涂层具有低热导率和良好的耐温性能,
能够降低涡轮叶片表面温度, 使高温结构件能在高于其熔点的环境中长时间高效率的服役 …

Finite-Temperature Mechanical Properties of Organic Molecular Crystals from Classical Molecular Simulation

M Brunsteiner, S Nilsson-Lil, LM Morgan… - Crystal Growth & …, 2023 - ACS Publications
The mechanical properties of crystalline materials can have an impact on different aspects of
solid dosage form design and manufacturing. Experimental determination of these quantities …

Preparation of long-lifetime thermal barrier coatings and toughening mechanism by using hierarchy structured zirconia-based microspheres

R Zhang, X Zhang, C Xing, L Hu, F Guo, X Wang… - Journal of the European …, 2021 - Elsevier
The thermal cycling lifetime of thermal barrier coatings was doubled when deposited by
electro-sprayed (ESP) microspheres instead of by commercial hollow spherical powders. It …

A modern approach to the Heckel Equation: The effect of compaction pressure on the yield pressure of ibuprofen and its sodium salt

D Hooper, FC Clarke, JC Mitchell… - … of Nanomedicine and …, 2016 - gala.gre.ac.uk
Despite being heavily criticised in the literature the most widely used and accepted
compaction equation is the Heckel equation proposed by Heckel in 1961. Its presence in …

How can single particle compression and nanoindentation contribute to the understanding of pharmaceutical powder compression?

I Wünsch, S Michel, JH Finke, E John, M Juhnke… - European Journal of …, 2021 - Elsevier
The deformation behaviour of a powder and, thus, of the individual particles is a crucial
parameter in powder compaction and affects powder compressibility and compactibility. The …

High Ratio of Hardness and Elastic Modulus (H/E) Studied by the Nanoindentation Technique of Acetaminophen with Corrugated Slip Planes

F Wei, W Zhang, C Zhang, Y Tian, S Wu… - Crystal Growth & …, 2022 - ACS Publications
Acetaminophen is a widely used analgesic and antipyretic drug. The mechanical properties
of drugs are vital for tableting and bioavailability. This paper studied the mechanical …