Spitz nevi and other spitzoid neoplasms in children: overview of incidence data and diagnostic criteria
Spitz nevi are benign melanocytic neoplasms characterized by epithelioid or spindle
melanocytes or both. In some rare cases their presentation overlaps with the clinical and …
melanocytes or both. In some rare cases their presentation overlaps with the clinical and …
Atypical Spitz tumors: a diagnostic challenge
KL Harms, L Lowe, DR Fullen… - Archives of pathology …, 2015 - meridian.allenpress.com
Spitzoid melanocytic lesions encompass a spectrum from benign Spitz nevi to malignant
spitzoid melanomas. Spitzoid melanocytic neoplasms have significant morphologic and …
spitzoid melanomas. Spitzoid melanocytic neoplasms have significant morphologic and …
[HTML][HTML] The genomic landscape of childhood and adolescent melanoma
C Lu, J Zhang, P Nagahawatte, J Easton, S Lee… - Journal of Investigative …, 2015 - Elsevier
Despite remarkable advances in the genomic characterization of adult melanoma, the
molecular pathogenesis of pediatric melanoma remains largely unknown. We analyzed 15 …
molecular pathogenesis of pediatric melanoma remains largely unknown. We analyzed 15 …
TERT Promoter Mutations Are Predictive of Aggressive Clinical Behavior in Patients with Spitzoid Melanocytic Neoplasms
S Lee, RL Barnhill, R Dummer, J Dalton, J Wu… - Scientific reports, 2015 - nature.com
Spitzoid neoplasms constitute a morphologically distinct category of melanocytic tumors,
encompassing Spitz nevus (benign), atypical Spitz tumor (intermediate malignant potential) …
encompassing Spitz nevus (benign), atypical Spitz tumor (intermediate malignant potential) …
A p16-Ki-67-HMB45 immunohistochemistry scoring system as an ancillary diagnostic tool in the diagnosis of melanoma
Background Melanoma is a skin cancer which treatment requires early diagnosis and large
surgical removal. The histopathological diagnosis of a melanocytic tumour is sometimes …
surgical removal. The histopathological diagnosis of a melanocytic tumour is sometimes …
Outcomes of atypical spitz tumors with chromosomal copy number aberrations and conventional melanomas in children
P Gerami, C Cooper, S Bajaj, A Wagner… - The American journal …, 2013 - journals.lww.com
Death due to melanoma in childhood (up to 20 y of age) is a rare event, with an average of
18 cases reported annually in the United States. In this study we evaluated 2 subgroups of …
18 cases reported annually in the United States. In this study we evaluated 2 subgroups of …
p16 expression: a marker of differentiation between childhood malignant melanomas and Spitz nevi
R Al Dhaybi, M Agoumi, I Gagné, C McCuaig… - Journal of the American …, 2011 - Elsevier
BACKGROUND: Childhood malignant melanomas frequently present as nodular
melanomas with Spitzoid features. Spitz nevus and Spitzoid melanoma overlap clinically …
melanomas with Spitzoid features. Spitz nevus and Spitzoid melanoma overlap clinically …
Prognostic factors for melanoma in children and adolescents: A clinicopathologic, single‐center study of 137 Patients
S Paradela, E Fonseca, S Pita‐Fernández… - Cancer, 2010 - Wiley Online Library
BACKGROUND: Cutaneous melanoma in childhood is rare; therefore, its prognostic factors
and biologic behavior and the effectiveness of adjuvant diagnostic techniques in this group …
and biologic behavior and the effectiveness of adjuvant diagnostic techniques in this group …
[HTML][HTML] The landscape of fusion transcripts in spitzoid melanoma and biologically indeterminate spitzoid tumors by RNA sequencing
G Wu, RL Barnhill, S Lee, Y Li, Y Shao, J Easton… - Modern Pathology, 2016 - Elsevier
Kinase activation by chromosomal translocations is a common mechanism that drives
tumorigenesis in spitzoid neoplasms. To explore the landscape of fusion transcripts in these …
tumorigenesis in spitzoid neoplasms. To explore the landscape of fusion transcripts in these …
Combined utility of p16 and BRAF V600E in the evaluation of spitzoid tumors: Superiority to PRAME and correlation with FISH
JL McAfee, R Scarborough, XS Jia… - Journal of …, 2023 - Wiley Online Library
Background Spitzoid melanocytic neoplasms are diagnostically challenging; criteria for
malignancy continue to evolve. The ability to predict chromosomal abnormalities with …
malignancy continue to evolve. The ability to predict chromosomal abnormalities with …