Spitz nevi are benign melanocytic neoplasms characterized by epithelioid or spindle
melanocytes or both. In some rare cases their presentation overlaps with the clinical and …

Spitzoid melanocytic lesions encompass a spectrum from benign Spitz nevi to malignant
spitzoid melanomas. Spitzoid melanocytic neoplasms have significant morphologic and …

Despite remarkable advances in the genomic characterization of adult melanoma, the
molecular pathogenesis of pediatric melanoma remains largely unknown. We analyzed 15 …

Spitzoid neoplasms constitute a morphologically distinct category of melanocytic tumors,
encompassing Spitz nevus (benign), atypical Spitz tumor (intermediate malignant potential) …

Background Melanoma is a skin cancer which treatment requires early diagnosis and large
surgical removal. The histopathological diagnosis of a melanocytic tumour is sometimes …

Death due to melanoma in childhood (up to 20 y of age) is a rare event, with an average of
18 cases reported annually in the United States. In this study we evaluated 2 subgroups of …

BACKGROUND: Childhood malignant melanomas frequently present as nodular
melanomas with Spitzoid features. Spitz nevus and Spitzoid melanoma overlap clinically …

BACKGROUND: Cutaneous melanoma in childhood is rare; therefore, its prognostic factors
and biologic behavior and the effectiveness of adjuvant diagnostic techniques in this group …

Kinase activation by chromosomal translocations is a common mechanism that drives
tumorigenesis in spitzoid neoplasms. To explore the landscape of fusion transcripts in these …

Background Spitzoid melanocytic neoplasms are diagnostically challenging; criteria for
malignancy continue to evolve. The ability to predict chromosomal abnormalities with …