Anti-cancer peptide-based therapeutic strategies in solid tumors

M Karami Fath, K Babakhaniyan, M Zokaei… - Cellular & Molecular …, 2022 - Springer
Background Nowadays, conventional medical treatments such as surgery, radiotherapy, and
chemotherapy cannot cure all types of cancer. A promising approach to treat solid tumors is …

Peptide-based agents for cancer treatment: current applications and future directions

NTT Nhàn, T Yamada, KH Yamada - International Journal of Molecular …, 2023 - mdpi.com
Peptide-based strategies have received an enormous amount of attention because of their
specificity and applicability. Their specificity and tumor-targeting ability are applied to …

Nanotechnology‐based electrochemical biosensors for monitoring breast cancer biomarkers

H Nasrollahpour, B Khalilzadeh… - Medicinal Research …, 2023 - Wiley Online Library
Breast cancer is categorized as the most widespread cancer type among women globally.
On‐time diagnosis can decrease the mortality rate by making the right decision in the …

MOrPH-PhD: an integrated phage display platform for the discovery of functional genetically encoded peptide macrocycles

AE Owens, JA Iannuzzelli, Y Gu, R Fasan - ACS central science, 2020 - ACS Publications
Macrocyclic peptides represent attractive scaffolds for targeting protein–protein interactions,
making methods for the diversification and functional selection of these molecules highly …

In Vitro Selection of Peptides and Proteins—Advantages of mRNA Display

MS Newton, Y Cabezas-Perusse, CL Tong… - ACS synthetic …, 2019 - ACS Publications
mRNA display is a robust in vitro selection technique that allows the selection of peptides
and proteins with desired functions from libraries of trillions of variants. mRNA display relies …

Fanconi anemia pathway as a prospective target for cancer intervention

W Liu, A Palovcak, F Li, A Zafar, F Yuan, Y Zhang - Cell & bioscience, 2020 - Springer
Fanconi anemia (FA) is a recessive genetic disorder caused by biallelic mutations in at least
one of 22 FA genes. Beyond its pathological presentation of bone marrow failure and …

Display selection of exotic macrocyclic peptides expressed under a radically reprogrammed 23 amino acid genetic code

T Passioura, W Liu, D Dunkelmann… - Journal of the …, 2018 - ACS Publications
Bioactive naturally occurring macrocyclic peptides often exhibit a strong bias for
hydrophobic residues. Recent advances in in vitro display technologies have made possible …

Expanding the chemical diversity of genetically encoded libraries

SE Iskandar, VA Haberman… - ACS combinatorial …, 2020 - ACS Publications
The power of ribosomes has increasingly been harnessed for the synthesis and selection of
molecular libraries. Technologies, such as phage display, yeast display, and mRNA display …

Highly Constrained Bicyclic Scaffolds for the Discovery of Protease-Stable Peptides via mRNA Display

DE Hacker, J Hoinka, ES Iqbal, TM Przytycka… - ACS chemical …, 2017 - ACS Publications
Highly constrained peptides such as the knotted peptide natural products are promising
medicinal agents because of their impressive biostability and potent activity. Yet, libraries of …

Isolation, Cytotoxicity Evaluation, Docking, ADMET and Drug Likeness Studies of Secondary Metabolites from the Stem Bark of Anthocephalus cadamba (Roxb.)

N Gupta, A Qayum, S Singh, S Mujwar… - …, 2022 - Wiley Online Library
Phytochemical investigation of the stem bark of Anthocephalus cadamba (Rubiaceae) led to
the isolation of total ten secondary metabolites (1‐10) including β–sitosterol (1), ursolic acid …