[HTML][HTML] Recent developments in the use of peroxygenases–Exploring their high potential in selective oxyfunctionalisations
Peroxygenases are an emerging new class of enzymes allowing selective
oxyfunctionalisation reactions in a cofactor-independent way different from well-known P450 …
oxyfunctionalisation reactions in a cofactor-independent way different from well-known P450 …
Oxidoreductases on their way to industrial biotransformations
Fungi produce heme-containing peroxidases and peroxygenases, flavin-containing
oxidases and dehydrogenases, and different copper-containing oxidoreductases involved in …
oxidases and dehydrogenases, and different copper-containing oxidoreductases involved in …
Selective aerobic oxidation reactions using a combination of photocatalytic water oxidation and enzymatic oxyfunctionalizations
W Zhang, E Fernández-Fueyo, Y Ni, M Van Schie… - Nature …, 2018 - nature.com
Peroxygenases offer an attractive means to address challenges in selective
oxyfunctionalization chemistry. Despite this, their application in synthetic chemistry remains …
oxyfunctionalization chemistry. Despite this, their application in synthetic chemistry remains …
Hydrogen peroxide driven biocatalysis
In general, hydrogen peroxide is a stable and relatively mild oxidant and it can be regarded
as the ultimate “green” reagent because water and oxygen are the only by-products …
as the ultimate “green” reagent because water and oxygen are the only by-products …
[HTML][HTML] Peroxygenases en route to becoming dream catalysts. What are the opportunities and challenges?
Y Wang, D Lan, R Durrani, F Hollmann - Current opinion in chemical …, 2017 - Elsevier
Highlights•Peroxygenases are very promising catalysts for preparative oxyfunctionalization
chemistry.•The number of interesting applications and novel catalysts is growing …
chemistry.•The number of interesting applications and novel catalysts is growing …
Repertoire of computationally designed peroxygenases for enantiodivergent C–H oxyfunctionalization reactions
P Gómez de Santos, I Mateljak, MD Hoang… - Journal of the …, 2023 - ACS Publications
The generation of enantiodivergent biocatalysts for C–H oxyfunctionalizations is ever more
important in modern synthetic chemistry. Here, we have applied the FuncLib algorithm …
important in modern synthetic chemistry. Here, we have applied the FuncLib algorithm …
Kinetic insights into the peroxygenase activity of cellulose-active lytic polysaccharide monooxygenases (LPMOs)
Lytic polysaccharide monooxygenases (LPMOs) are widely distributed in Nature, where they
catalyze the hydroxylation of glycosidic bonds in polysaccharides. Despite the importance of …
catalyze the hydroxylation of glycosidic bonds in polysaccharides. Despite the importance of …
Enzymatic Hydroxylations of sp3-Carbons
Enzymatic hydroxylation of activated and nonactivated sp3-carbons attracts keen interest
from the chemistry community as it is one of the most challenging tasks in organic synthesis …
from the chemistry community as it is one of the most challenging tasks in organic synthesis …
Improving and repurposing biocatalysts via directed evolution
Highlights•Directed evolution has become a proven method to engineer biocatalysts' overall
performance.•New library creation and screening approaches are at the base of directed …
performance.•New library creation and screening approaches are at the base of directed …
Current state and future perspectives of engineered and artificial peroxygenases for the oxyfunctionalization of organic molecules
MC Sigmund, GJ Poelarends - Nature Catalysis, 2020 - nature.com
Peroxygenases are attractive biocatalysts for the selective introduction of oxygen into
organic molecules under mild conditions with hydrogen peroxide as the oxygen source. In …
organic molecules under mild conditions with hydrogen peroxide as the oxygen source. In …