Urinary tract infections: microbial pathogenesis, host–pathogen interactions and new treatment strategies

RD Klein, SJ Hultgren - Nature Reviews Microbiology, 2020 - nature.com
Urinary tract infections (UTIs) are common, recurrent infections that can be mild to life-
threatening. The continued emergence of antibiotic resistance, together with our increasing …

Reaching the end of the line: urinary tract infections

KO Tamadonfar, NS Omattage… - Microbiology …, 2019 - Am Soc Microbiol
Urinary tract infections (UTIs) cause a substantial health care burden. UTIs (i) are most often
caused by uropathogenic Escherichia coli (UPEC),(ii) primarily affect otherwise healthy …

Protein nanowires with tunable functionality and programmable self-assembly using sequence-controlled synthesis

DM Shapiro, G Mandava, SE Yalcin… - Nature …, 2022 - nature.com
Advances in synthetic biology permit the genetic encoding of synthetic chemistries at
monomeric precision, enabling the synthesis of programmable proteins with tunable …

Structural basis for Acinetobacter baumannii biofilm formation

N Pakharukova, M Tuittila… - Proceedings of the …, 2018 - National Acad Sciences
Acinetobacter baumannii—a leading cause of nosocomial infections—has a remarkable
capacity to persist in hospital environments and medical devices due to its ability to form …

Archaeal bundling pili of Pyrobaculum calidifontis reveal similarities between archaeal and bacterial biofilms

F Wang, V Cvirkaite-Krupovic… - Proceedings of the …, 2022 - National Acad Sciences
While biofilms formed by bacteria have received great attention due to their importance in
pathogenesis, much less research has been focused on the biofilms formed by archaea. It …

Electron cryo-microscopy reveals the structure of the archaeal thread filament

MC Gaines, MN Isupov, S Sivabalasarma… - Nature …, 2022 - nature.com
Pili are filamentous surface extensions that play roles in bacterial and archaeal cellular
processes such as adhesion, biofilm formation, motility, cell-cell communication, DNA …

Adhesins of yeasts: protein structure and interactions

RG Willaert - Journal of Fungi, 2018 - mdpi.com
The ability of yeast cells to adhere to other cells or substrates is crucial for many yeasts. The
budding yeast Saccharomyces cerevisiae can switch from a unicellular lifestyle to a …

Classical chaperone-usher (CU) adhesive fimbriome: uropathogenic Escherichia coli (UPEC) and urinary tract infections (UTIs)

P Behzadi - Folia microbiologica, 2020 - Springer
The presence of a diversity of virulence factors such as Chaperone-Usher (CU) fibers in
uropathogenic Escherichia coli (UPEC) pathotypes virulome has offered these bacteria a …

TapA acts as specific chaperone in TasA filament formation by strand complementation

Y Roske, F Lindemann, A Diehl… - Proceedings of the …, 2023 - National Acad Sciences
Studying mechanisms of bacterial biofilm generation is of vital importance to understanding
bacterial cell–cell communication, multicellular cohabitation principles, and the higher …

Functional role of the type 1 pilus rod structure in mediating host-pathogen interactions

CN Spaulding, HL Schreiber IV, W Zheng, KW Dodson… - Elife, 2018 - elifesciences.org
Uropathogenic E. coli (UPEC), which cause urinary tract infections (UTI), utilize type 1 pili, a
chaperone usher pathway (CUP) pilus, to cause UTI and colonize the gut. The pilus rod …