Transcription factors play an indispensable role in maintaining cellular viability and finely
regulating complex internal metabolic networks. These crucial bioactive functions rely on …

The interbacterial deaminase toxin DddA catalyzes cytosine-to-uracil conversion in double-
stranded (ds) DNA and enables CRISPR-free mitochondrial base editing, but the molecular …

DddA-derived cytosine base editors (DdCBEs) greatly facilitated the basic and therapeutic
research of mitochondrial DNA mutation diseases. Here we devise a saturated spacer …

Microbes typically live in complex habitats, where they need to rapidly adapt to continuously
changing growth conditions. To do so, they produce an astonishing array of natural products …

Pseudomonas aeruginosa can cause a wide array of chronic and acute infections
associated with its ability to rapidly switch between planktonic, biofilm, and dispersed …

Streptomyces are a genus of ubiquitous soil bacteria from which the majority of clinically
utilized antibiotics derive. The production of these antibacterial molecules reflects the …

Integrating and analyzing multiple omics data sets, including genomics, proteomics and
radiomics, can significantly advance researchers' comprehensive understanding of …

Mechanisms of protein-DNA interactions are involved in a wide range of biological activities
and processes. Accurately identifying binding sites between proteins and DNA is crucial for …

Efficient and accurate recognition of protein–DNA interactions is vital for understanding the
molecular mechanisms of related biological processes and further guiding drug discovery …

Describing the microbial community within the tumour has been a key aspect in
understanding the pathophysiology of the tumour microenvironment. In head and neck …