Reverse Genetics Systems for Emerging and Re-Emerging Swine Coronaviruses and Applications
H Jiang, T Wang, L Kong, B Li, Q Peng - Viruses, 2023 - mdpi.com
Emerging and re-emerging swine coronaviruses (CoVs), including porcine epidemic
diarrhea virus (PEDV), porcine deltacoronavirus (PDCoV), and swine acute diarrhea …
diarrhea virus (PEDV), porcine deltacoronavirus (PDCoV), and swine acute diarrhea …
Reprogramming viral immune evasion for a rational design of next-generation vaccines for RNA viruses
CM Su, Y Du, RRR Rowland, Q Wang… - Frontiers in …, 2023 - frontiersin.org
Type I interferons (IFNs-α/β) are antiviral cytokines that constitute the innate immunity of
hosts to fight against viral infections. Recent studies, however, have revealed the pleiotropic …
hosts to fight against viral infections. Recent studies, however, have revealed the pleiotropic …
Deletion of a 7-amino-acid region in the porcine epidemic diarrhea virus envelope protein induces higher type I and III interferon responses and results in attenuation …
Z Li, Z Ma, W Han, C Chang, Y Li, X Guo… - Journal of …, 2023 - Am Soc Microbiol
Porcine epidemic diarrhea virus (PEDV) leads to enormous economic losses for the pork
industry. However, the commercial vaccines failed to fully protect against the epidemic …
industry. However, the commercial vaccines failed to fully protect against the epidemic …
Isolation, identification, and pathogenicity of porcine epidemic diarrhea virus
Y Sun, T Gong, D Wu, Y Feng, Q Gao, J Xing… - Frontiers in …, 2023 - frontiersin.org
Porcine epidemic diarrhea (PED) is an enterophilic infectious disease caused by the porcine
epidemic diarrhea virus (PEDV), which can lead to dehydration-like diarrhea in piglets with a …
epidemic diarrhea virus (PEDV), which can lead to dehydration-like diarrhea in piglets with a …
PEDV evades MHC-I-related immunity through nsp1-mediated NLRC5 translation inhibition
X Liu, M Zhang, L Yin, L Kang, Y Luo, X Wang… - Journal of …, 2024 - journals.asm.org
Major histocompatibility complex class I (MHC-I) plays crucial roles against viral infections
not only by initiating CD8+ T cell immunity but also by modulating natural killer (NK) cell …
not only by initiating CD8+ T cell immunity but also by modulating natural killer (NK) cell …
Development of a safe and broad-spectrum attenuated PEDV vaccine candidate by S2 subunit replacement
D Zhang, Y Xie, Q Liao, Z Jiao, R Liang… - Journal of …, 2024 - journals.asm.org
Porcine epidemic diarrhea (PED) has caused serious economic losses to the swine
livestock industry. Due to the rapid variation in the PEDV) genome, especially the spike (S) …
livestock industry. Due to the rapid variation in the PEDV) genome, especially the spike (S) …
SADS-CoV nsp1 inhibits the STAT1 phosphorylation by promoting K11/K48-linked polyubiquitination of JAK1 and blocks the STAT1 acetylation by degrading CBP
Y Xiang, C Mou, L Zhu, Z Wang, K Shi, W Bao… - Journal of Biological …, 2024 - ASBMB
The newly discovered zoonotic coronavirus swine acute diarrhea syndrome coronavirus
(SADS-CoV) causes acute diarrhea, vomiting, dehydration, and high mortality rates in …
(SADS-CoV) causes acute diarrhea, vomiting, dehydration, and high mortality rates in …
Progress of research on coronaviruses and toroviruses in large domestic animals using reverse genetics systems
M Ujike, T Suzuki - The Veterinary Journal, 2024 - Elsevier
The generation of genetically engineered recombinant viruses from modified DNA/RNA is
commonly referred to as reverse genetics, which allows the introduction of desired mutations …
commonly referred to as reverse genetics, which allows the introduction of desired mutations …
Developing Next-Generation Live Attenuated Vaccines for Porcine Epidemic Diarrhea Using Reverse Genetic Techniques
R Yu, S Dong, B Chen, F Si, C Li - Vaccines, 2024 - mdpi.com
Porcine epidemic diarrhea virus (PEDV) is the etiology of porcine epidemic diarrhea (PED),
a highly contagious digestive disease in pigs and especially in neonatal piglets, in which a …
a highly contagious digestive disease in pigs and especially in neonatal piglets, in which a …
A Comprehensive View on the Protein Functions of Porcine Epidemic Diarrhea Virus
Porcine epidemic diarrhea (PED) virus (PEDV) is one of the main pathogens causing
diarrhea in piglets and fattening pigs. The clinical signs of PED are vomiting, acute diarrhea …
diarrhea in piglets and fattening pigs. The clinical signs of PED are vomiting, acute diarrhea …