Causal roles of mitochondrial dynamics in longevity and healthy aging
Mitochondria are organized in the cell in the form of a dynamic, interconnected network.
Mitochondrial dynamics, regulated by mitochondrial fission, fusion, and trafficking, ensure …
Mitochondrial dynamics, regulated by mitochondrial fission, fusion, and trafficking, ensure …
Mitochondria damage and kidney disease
P Duann, PH Lin - Mitochondrial Dynamics in cardiovascular medicine, 2017 - Springer
The kidney is a vital organ that demands an extraordinary amount of energy to actively
maintain the body's metabolism, plasma hemodynamics, electrolytes and water …
maintain the body's metabolism, plasma hemodynamics, electrolytes and water …
[HTML][HTML] Nicotinamide provides neuroprotection in glaucoma by protecting against mitochondrial and metabolic dysfunction
JR Tribble, A Otmani, S Sun, SA Ellis, G Cimaglia… - Redox biology, 2021 - Elsevier
Nicotinamide adenine dinucleotide (NAD) is a REDOX cofactor and metabolite essential for
neuronal survival. Glaucoma is a common neurodegenerative disease in which neuronal …
neuronal survival. Glaucoma is a common neurodegenerative disease in which neuronal …
Sirtuins in renal health and disease
Sirtuins belong to an evolutionarily conserved family of NAD+-dependent deacetylases that
share multiple cellular functions related to proliferation, DNA repair, mitochondrial energy …
share multiple cellular functions related to proliferation, DNA repair, mitochondrial energy …
Human mesenchymal stromal cells transplanted into mice stimulate renal tubular cells and enhance mitochondrial function
Mesenchymal stromal cells (MSCs) are renoprotective and drive regeneration following
injury, although cellular targets of such an effect are still ill-defined. Here, we show that …
injury, although cellular targets of such an effect are still ill-defined. Here, we show that …
SIRT3 promotes antimycobacterial defenses by coordinating mitochondrial and autophagic functions
ABSTRACT SIRT3 (sirtuin 3), a mitochondrial protein deacetylase, maintains respiratory
function, but its role in the regulation of innate immune defense is largely unknown. Herein …
function, but its role in the regulation of innate immune defense is largely unknown. Herein …
Melatonin mitigates mitochondrial meltdown: interactions with SIRT3
Melatonin exhibits extraordinary diversity in terms of its functions and distribution. When
discovered, it was thought to be uniquely of pineal gland origin. Subsequently, melatonin …
discovered, it was thought to be uniquely of pineal gland origin. Subsequently, melatonin …
Diabetic nephropathy: novel molecular mechanisms and therapeutic targets
C Zoja, C Xinaris, D Macconi - Frontiers in pharmacology, 2020 - frontiersin.org
Diabetic nephropathy (DN) is one of the major microvascular complications of diabetes
mellitus and the leading cause of end-stage kidney disease. The standard treatments for …
mellitus and the leading cause of end-stage kidney disease. The standard treatments for …
Sirtuin 3 regulates mitochondrial protein acetylation and metabolism in tubular epithelial cells during renal fibrosis
Y Zhang, P Wen, J Luo, H Ding, H Cao, W He… - Cell death & …, 2021 - nature.com
Proximal tubular epithelial cells (TECs) demand high energy and rely on mitochondrial
oxidative phosphorylation as the main energy source. However, this is disturbed in renal …
oxidative phosphorylation as the main energy source. However, this is disturbed in renal …
The role of SIRT3-mediated mitochondrial homeostasis in osteoarthritis
Y He, Z Wu, L Xu, K Xu, Z Chen, J Ran, L Wu - Cellular and Molecular Life …, 2020 - Springer
Osteoarthritis is the most common degenerative joint disease and causes major pain and
disability in adults. It has been reported that mitochondrial dysfunction in chondrocytes is …
disability in adults. It has been reported that mitochondrial dysfunction in chondrocytes is …