The neuromuscular junction in health and disease: molecular mechanisms governing synaptic formation and homeostasis

PM Rodríguez Cruz, J Cossins, D Beeson… - Frontiers in molecular …, 2020 - frontiersin.org
The neuromuscular junction (NMJ) is a highly specialized synapse between a motor neuron
nerve terminal and its muscle fiber that are responsible for converting electrical impulses …

Neuromuscular junction formation, aging, and disorders

L Li, WC Xiong, L Mei - Annual review of physiology, 2018 - annualreviews.org
Synapses, the fundamental unit in neuronal circuits, are critical for learning and memory,
perception, thinking, and reaction. The neuromuscular junction (NMJ) is a synapse formed …

[HTML][HTML] Mechanisms regulating neuromuscular junction development and function and causes of muscle wasting

LA Tintignac, HR Brenner… - Physiological …, 2015 - journals.physiology.org
The neuromuscular junction is the chemical synapse between motor neurons and skeletal
muscle fibers. It is designed to reliably convert the action potential from the presynaptic …

Cellular and molecular anatomy of the human neuromuscular junction

RA Jones, C Harrison, SL Eaton, ML Hurtado… - Cell reports, 2017 - cell.com
The neuromuscular junction (NMJ) plays a fundamental role in transferring information from
lower motor neuron to skeletal muscle to generate movement. It is also an experimentally …

FUS-mediated regulation of acetylcholine receptor transcription at neuromuscular junctions is compromised in amyotrophic lateral sclerosis

G Picchiarelli, M Demestre, A Zuko, M Been… - Nature …, 2019 - nature.com
Neuromuscular junction (NMJ) disruption is an early pathogenic event in amyotrophic lateral
sclerosis (ALS). Yet, direct links between NMJ pathways and ALS-associated genes such as …

The neuromuscular junction: roles in aging and neuromuscular disease

SR Iyer, SB Shah, RM Lovering - International journal of molecular …, 2021 - mdpi.com
The neuromuscular junction (NMJ) is a specialized synapse that bridges the motor neuron
and the skeletal muscle fiber and is crucial for conversion of electrical impulses originating …

The Hippo pathway effector YAP is a critical regulator of skeletal muscle fibre size

KI Watt, BJ Turner, A Hagg, X Zhang, JR Davey… - Nature …, 2015 - nature.com
The Yes-associated protein (YAP) is a core effector of the Hippo pathway, which regulates
proliferation and apoptosis in organ development. YAP function has been extensively …

A compartmentalized microfluidic neuromuscular co-culture system reveals spatial aspects of GDNF functions

EE Zahavi, A Ionescu, S Gluska… - Journal of cell …, 2015 - journals.biologists.com
Bidirectional molecular communication between the motoneuron and the muscle is vital for
neuromuscular junction (NMJ) formation and maintenance. The molecular mechanisms …

The role of oxidative stress in degeneration of the neuromuscular junction in amyotrophic lateral sclerosis

E Pollari, G Goldsteins, G Bart, J Koistinaho… - Frontiers in cellular …, 2014 - frontiersin.org
Amyotrophic lateral sclerosis (ALS) is characterized by the progressive loss of motoneurons
and degradation of the neuromuscular junctions (NMJ). Consistent with the dying-back …

LRP4 is critical for neuromuscular junction maintenance

A Barik, Y Lu, A Sathyamurthy, A Bowman… - Journal of …, 2014 - Soc Neuroscience
The neuromuscular junction (NMJ) is a synapse between motor neurons and skeletal
muscle fibers, and is critical for control of muscle contraction. Its formation requires neuronal …