The prevalence of autoimmune diseases (ADs) worldwide has rapidly increased over the
past few decades. Thus, in addition to the classical risk factors for ADs, such as genetic …

Systemic inflammation has been suggested to have a pivotal role in atherothrombosis, but
the factors that trigger systemic inflammation have not been fully elucidated …

Objective Type 1 diabetes (T1D) is characterised by islet autoimmunity and beta cell
destruction. A gut microbiota–immunological interplay is involved in the pathophysiology of …

Despite multiple associations between the microbiota and immune diseases, their role in
autoimmunity is poorly understood. We found that translocation of a gut pathobiont …

The small intestine contains CD4+ CD8αα+ double-positive intraepithelial lymphocytes (DP
IELs), which originate from intestinal CD4+ T cells through down-regulation of the …

In the mucosa, the immune system's T cells and B cells have position-specific phenotypes
and functions that are influenced by the microbiota. These cells play pivotal parts in the …

Type 2 diabetes mellitus (T2D) is a highly prevalent metabolic disorder characterized by an
imbalance in blood glucose level, altered lipid profile and high blood pressure. Genetic …

The composition of the gut microbiota is in constant flow under the influence of factors such
as the diet, ingested drugs, the intestinal mucosa, the immune system, and the microbiota …

The role of gut microbes in health and disease has often been surmised from stool, which is
easily sampled and rich in microbial diversity, density, and abundance. Microbial analyses …

Dietary lipids may influence the abundance of circulating inflammatory microbial factors.
Hence, inflammation in white adipose tissue (WAT) induced by dietary lipids may be partly …