Thyroid cancer is rare in the pediatric population, but thyroid carcinomas occurring in
children carry a unique set of clinical, pathologic, and molecular characteristics. In …

Genetic alteration is the driving force for thyroid tumorigenesis and progression, based upon
which novel approaches to the management of thyroid cancer can be developed. A recent …

Context: Telomerase promoter mutations (TERT) were recently described in follicular cell-
derived thyroid carcinomas (FCDTC) and seem to be more prevalent in aggressive cancers …

Thyroid cancer is one of the few malignancies that are increasing in incidence. Recent
advances have improved our understanding of its pathogenesis; these include the …

The variety of diseases caused by mutations in RET receptor tyrosine kinase provides a
classic example of phenotypic heterogeneity. Gain-of-function mutations of RET are …

According to the literature thyroid nodules are quite rare in the first two decades of life.
However, there are some exceptions, relating to areas with an iodine deficiency or affected …

Pediatric thyroid cancer is a rare disease with an excellent prognosis. Compared with adults,
epithelial-derived differentiated thyroid cancer (DTC), which includes papillary and follicular …

Context: The clinicopathological characteristics and the molecular features of the follicular
variant of papillary thyroid carcinoma (FVPTC) remain controversial. Objective/Design …

Of the RAF family of protein kinases, BRAF is the only member to be frequently activated by
mutation in cancer. A single amino acid substitution (V600E) accounts for the vast majority …

Thyroid papillary carcinoma is the most common type of endocrine cancer. It is frequently
associated with genetic alterations leading to activation of the MAPK signaling pathway. The …